Postgraduate Specialisation in Psychiatry


Course code
Name of lecturer
Giovanni Gotte
Number of ECTS credits allocated
Other available courses
Academic sector
Language of instruction
not yet allocated

Learning outcomes

Knowledge of brain metabolism and of the main neurotransmitters. Pathophysiological aspects.
Link between neurodegenerative diseases and aberrant protein aggregation events.


Hints on metabolism in general. Metabolism of the brain: anaerobic, glucose metabolism. Ketogenesis and use of ketone bodies. Glutamate and glutamine. Pathophysiology of nervous system metabolism.
Nerve impulse transmission. Excitatory and inhibitory neurotransmitters. Neurotransmitters derived from amino acids and not. Dopaminergic and non-dopaminergic. Notes on enzymatic defects involved in the synthesis and/or regulation of neurotransmitters.
Proteins, notes on structural aspects. Aberrant structures of protein aggregates and neurodegenerative diseases. Organ-specific and/or systemic amyloidosis. Amyloid fibrils and pathological effects.
Toxic and/or non-toxic protein oligomers. Protein aggregation mechanisms. Intimate structure of the fibrils and structural polymorphisms. Complete structure of the fibrils thanks to the "Cryo-EM" microscopy technique. Molecules interfering with fibrils and new possible therapeutic perspectives.

Reference books

See the teaching bibliography

Assessment methods and criteria

No exam is foreseen

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