Knowledge of brain metabolism and of the main neurotransmitters. Pathophysiological aspects.
Link between neurodegenerative diseases and aberrant protein aggregation events.
Hints on metabolism in general. Metabolism of the brain: anaerobic, glucose metabolism. Ketogenesis and use of ketone bodies. Glutamate and glutamine. Pathophysiology of nervous system metabolism.
Nerve impulse transmission. Excitatory and inhibitory neurotransmitters. Neurotransmitters derived from amino acids and not. Dopaminergic and non-dopaminergic. Notes on enzymatic defects involved in the synthesis and/or regulation of neurotransmitters.
Proteins, notes on structural aspects. Aberrant structures of protein aggregates and neurodegenerative diseases. Organ-specific and/or systemic amyloidosis. Amyloid fibrils and pathological effects.
Toxic and/or non-toxic protein oligomers. Protein aggregation mechanisms. Intimate structure of the fibrils and structural polymorphisms. Complete structure of the fibrils thanks to the "Cryo-EM" microscopy technique. Molecules interfering with fibrils and new possible therapeutic perspectives.
No exam is foreseen