Combined Bachelor's + Master's degree in Medicine and Surgery

Genetics and Molecular Biology - BIOLOGIA MOLECOLARE

Course code
Name of lecturer
Donato Zipeto
Number of ECTS credits allocated
Academic sector
Language of instruction
1° semestre dal Oct 1, 2020 al Dec 23, 2020.

To show the organization of the course that includes this module, follow this link * Course organization

Lesson timetable

Go to lesson schedule

Learning outcomes

To understand the fundamental processes of the science of DNA and the flow of information that leads from DNA to RNA to proteins.
To understand mechanisms, function and regulation of these processes.
To educate medical students to the scientific method through the description of experiments that allowed the elucidation of molecular biological mechanisms.
To understand recombinant DNA technologies and their potential.

Upon completing the course, students will be able to understand the main molecular mechanisms underlying the regulation of gene expression and how these knowledge can be applied in the field of modern biomedicine.


• Structure and conformations of DNA
• Complexity of genomic DNA • DNA structure in chromosomes • DNA replication
• DNA repair
• Recombination
• Transcription in prokaryotes and eukaryotes
• Maturation of RNA
• Genetic Code
• Translation
• Regulation of gene expression in prokaryotes
• Regulation of gene expression in eukaryotes
• Degradation and trafficking of proteins
• DNA recombinant technology and recombinant DNA
• Molecular evolution
• An outline of gene therapy

Lessons in dual mode (in presence and distance)
Learning materials and recordings available on the Moodle platform

Reference books
Author Title Publisher Year ISBN Note
Amaldi, Benedetti, Pesole, Plevani Biologia Molecolare (Edizione 3) Ambrosiana 2018 978-88-08-18518-1
Zlatanova, Van Holde Biologia Molecolare (Edizione 1) Zanichelli 2018 978-88-08-92089-8
Watson, Baker, Bell, Gann, Levine, Losick Biologia Molecolare del Gene (Edizione 7) Zanichelli 2019 978-88-08-36480-7
T.A. Brown Genomi 4 (Edizione 4) EdiSES 2018 978-88-7959-851-4

Assessment methods and criteria

The exam consists of a written test containing 30 multiple-choice questions.
There is also an open question to which the student should anser in a concise, precise, clear and organic way.
Students who will pass the written test will be admitted to a short oral exam, during which topics related to the course will be discussed.

NOTE: Should the need to hold the exams in telematic mode continue, the University and the Ministry's instructions will be followed.
The remote mode is guaranteed for all students who will ask for it in the academic year 2020/21.

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