Postgraduate Specialisation in Clinical Pathology and Clinical Biochemistry

Clinical biochemistry and clinical molecular biology

Course code
Name of lecturer
Giuseppe Lippi
Giuseppe Lippi
Number of ECTS credits allocated
Academic sector
Language of instruction
not yet allocated

Learning outcomes

Knowledge of laboratory test pathophysiological mechanisms and interpretation relating to individual organs and systems, for to the following topics:
Blood count, blood coagulation system, glucose metabolism and diabetes, lipid metabolism and atherosclerosis, acid-base and electrolyte balance, and plasma proteins of inflammation, renal function, liver function, enzymes in the diagnosis and monitoring, Tumor markers, Major changes endocrine (thyroid, adrenals, gonads, metabolism phosphocalcic), monitoring of pregnancy, normal karyotype, molecular biology applications and outline their main genetic diseases, monitoring of drugs.


At the end of the course the student:
1) Will know the general interpretation of the laboratory test criteria based on concepts of normality, reference intervals, analytical and biological variability intra- and interindividual. Will be able to interpret the diagnostic value of laboratory tests: specificity, sensitivity, positive and negative predictive value.
2) Will know the basic principles of laboratory methods in pre-analytical phase (sampling, processing and storage of samples), in the analytical phase (basic principles and implementation of the most important laboratory techniques), and post-analytical phase (collection, processing and reporting of data, quality control).
3) Will know the meaning underlying pathophysiological alterations of laboratory indices, and will integrate these changes with signs and symptoms detected clinically by history and physical examination to arrive at an interpretation of the most important diagnostic clinical syndromes.
4) Based on the pathophysiological significance and clinical laboratory test will recognize the motivations of test requests, the logic and semiologic value of individual tests in typical clinical cases.

Reference books
Author Title Publisher Year ISBN Note
Ciaccio M, Lippi G Biochimica Clinica e Medicina di Laboratorio (Edizione 2017) EdiSES Edizioni Scientifiche ed Universitarie 2017 9788879599580

Assessment methods and criteria

Written in text-structured MCQ, short integrated clinical cases, with answers to MCQ, interpretation of laboratory data. Oral exam of Laboratory Medicine provided the student has passed the written test.

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