Combined Bachelor's + Master's degree in Medicine and Surgery

Diagnosis of Disease based on the laboratory analysis: from theory to practice  (Corso Elettivo)

Course code
Name of lecturer
Gian Luca Salvagno
Gian Luca Salvagno
Number of ECTS credits allocated
Academic sector
Language of instruction
2° semestre dal Feb 22, 2021 al May 28, 2021.

Lesson timetable

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Learning outcomes

Objectives of the Elective Course

In the present elective course will be taken into consideration:
1. The role of Laboratory Medicine in the diagnostic process and in the monitoring of pathologies and drugs. Particular attention will be given to the interpretation of laboratory tests that concern the diagnosis of the main cardiovascular, haematological and metabolic diseases, discussing some clinical cases.
2. The appropriate methodology in the collection and processing of biological samples;
3. The pre-analytical, analytical and post-analytical variables that can influence the reliability of laboratory results.


At the end of the course the student:
1) Will know the general interpretation of the laboratory test criteria based on concepts of normality, reference intervals, analytical and biological variability intra- and interindividual. Will be able to interpret the diagnostic value of laboratory tests: specificity, sensitivity, positive and negative predictive value.
2) Will know the basic principles of laboratory methods in pre-analytical phase (sampling, processing and storage of samples), in the analytical phase (basic principles and implementation of the most important laboratory techniques), and post-analytical phase (collection, processing and reporting of data, quality control).
3) Will know the meaning underlying pathophysiological alterations of laboratory indices, and will integrate these changes with signs and symptoms detected clinically by history and physical examination to arrive at an interpretation of the most important diagnostic clinical syndromes.
4) Based on the pathophysiological significance and clinical laboratory test will recognize the motivations of test requests, the logic and semiologic value of individual tests in typical clinical cases.

Reference books
Author Title Publisher Year ISBN Note
Ciaccio M, Lippi G Biochimica Clinica e Medicina di Laboratorio (Edizione 2017) EdiSES Edizioni Scientifiche ed Universitarie 2017 9788879599580
Richard A. McPherson, MD, MSc and Matthew R. Pincus, MD, PhD Henry's Clinical Diagnosis and Management by Laboratory Methods (Edizione 23) ELSEVIER 2017 978-0-323-41315-2
Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 6th Edition Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 6th Edition (Edizione 6) ELSEVIER 2017 9780323359214

Assessment methods and criteria


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