Bachelor's degree in Nursing (to qualify as a nurse) (Vicenza)

Pathophysiology applied at Nursing - FARMACOLOGIA GENERALE

Course code
4S000090
Name of lecturer
Laura Cuzzolin
Number of ECTS credits allocated
2
Academic sector
BIO/14 - PHARMACOLOGY
Language of instruction
Italian
Location
VICENZA
Period
INF VI 1° ANNO 2° SEM dal Feb 1, 2021 al Apr 2, 2021.

To show the organization of the course that includes this module, follow this link * Course organization

Lesson timetable

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Learning outcomes

The Course is targeted to give to the student basic knowledge and methodological instruments required to do nursing service in the management and monitoring of pharmacological therapies. The Course also covers the study of basic principles of pharmacology, in particular pharmacokinetic and pharmacodynamic mechanisms, and introduces the student to the understanding and assessment of the benefits and risks of major therapeutic approaches.

Syllabus

GENERAL PRINCIPLES OF PHARMACOLOGY
Definition of drug, medicinal product, generic drug, biosimilar, galenic and magistral preparations.
Origin of drugs and the process of drug development.
The market of drugs in Italy.
Leaflet of drugs.
Off-label use.
International Classification System of drugs.
Defined Daily Dose (DDD).
Symptomatic, curative, preventive and substitutive drugs.
Different actions of drugs: systemic or local, direct or indirect, primary or secondary, collateral,
early or late onset.
Pharmacokinetics: absorption (mechanisms, routes of administration, formulations), distribution (plasma protein binding, tissue vascularization, blood-brain barrier and placental transfer of drugs), biotransformation reactions and excretion of drugs. Pharmacokinetic parameters: bioavailability, volume of distribution, elimination half-life,
clearance.
Pharmacodynamics: general mechanisms of action, receptor definition, drug-receptor interaction, agonism and antagonism, affinity and intrinsic activity of drugs.
ADVERSE DRUG REACTIONS AND TOXICOLOGY
Clinical risks related to drug use: therapeutic errors and classification of adverse drug reactions.
Pharmacovigilance: spontaneous reporting and the role of nurse.
Drug dependence.
Embryo-fetal toxicity.
PHARMACOTHERAPY
The concepts of risk/benefit and cost/benefit applied to drug treatments.
“Placebo” and “Compliance” definitions.
Dosage, maximum dose, effective dose, posology, therapeutic index.
Therapeutic plasma levels of drugs, peak concentrations, therapeutic range, accumulation, toxic concentrations.
Therapeutic drug monitoring.
Drug interactions.
Variability in drug response: therapeutic problems in neonates and children, elderly, patients with renal or hepatic insufficiency.
Antimicrobial therapy: selective toxicity, spectrum of action, bacteriostatic and bactericidal activity, microbial resistance. Pharmacological characteristics and adverse effects of the most important groups of antibiotics, antifungals and antivirals.
Non-steroidal antiinflammatory drugs and paracetamol.

Reference books
Author Title Publisher Year ISBN Note
Marina Vanzetta Roberto Leone Maurizio Volterrani Farmaci e infermiere. Un prontuario per la somministrazione McGraw-Hill Education 2013
Taglialatela Conforti Cuzzolin Leone Mattioli Moretti Pignataro Vanzetta Farmacologia per le lauree triennali e magistrali II Edizione (Edizione 2) Sorbona 2019
Clark M.A., Finkel R., Rey J.A., Whalen K. Le basi della farmacologia Zanichelli 2013 978-88-08-18864-9

Assessment methods and criteria

Learning evaluation of General Pharmacology is made inside the written exam "Pathophysiology applied at Nursing": 15 questions are provided through multiple-choice (2 correct between 5) or semi-structured answers.





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