Scuola di Specializzazione in Microbiologia e Virologia (accesso riservato ai "non medici" - D.I. 716/2016)

Biochemistry

Course code
4S00103
Name of lecturer
Ilaria Dando
Number of ECTS credits allocated
2
Academic sector
BIO/10 - BIOCHEMISTRY
Language of instruction
Italian
Site
VERONA
Period
not yet allocated

Learning outcomes

The course aims to provide knowledge on: - hallmarks of cancer; - metabolic characteristics of tumor cells; - biological and biochemical characteristics of tumor stem cells; - oncometabolites; - metabolic enzymes: other functions to support tumor proliferation; - cutting-edge technologies used in research to study the biochemistry of tumors; - new potential biochemical markers for the diagnosis of neoplasia; - female tumors and male tumors; - infections leading to the onset of neoplasms; - variants of the LHCGR receptor and its potential role in the development of male tumors; - connection between neoplasm and fertile potential in males. At the end of the course, the students will individually or in groups explain a topic of their choice present in the literature or based on their specialization experience, referring to the topics covered in class with the aim of showing a critical and applicative vision of the biochemistry of tumors.

Syllabus

During the course the following topics will be covered: the definition of cancer hallmarks according to Douglas Hanahan and Robert Weinberg; the metabolic characteristics of tumor cells, with particular reference to the Warburg effect and its interpretation today based on the most recent scientific works published in the literature; from the first discoveries to the latest scientific evidence on cancer stem cells; the metabolic characteristics of tumor stem cells; definition of oncometabolites and their role in supporting tumor proliferation and metastasis; the various functions of the most well-known metabolic enzymes in cancer; exhibition of the technologies used in research to study the biochemistry of tumors; new potential biochemical markers for the diagnosis of neoplasia; classification of the most common female and male tumors; cause-effect of some types of infections in the onset of certain neoplasms; role of hormones in tumorigenesis and variants of the luteinizing hormone receptor (LHCGR) in the development of male tumors; influence of the development of neoplasms on the alteration of fertile potential in males.

Assessment methods and criteria

At the end of the course, the students will individually or in groups explain a topic of their choice present in the literature or based on their specialization experience, referring to the topics covered in class with the aim of showing a critical and applicative vision of the biochemistry of tumors.



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