To show the organization of the course that includes this module, follow this link Course organization
The course is mostly focused on the relationship between structure and function of biological macromolecules and the main metabolic pathways in which they are involved.
The fundamental objective is to stimulate the student's interest in biomolecular science by highlighting interconnections between biochemical processes and related energetics.
At the end of the Course the student should demonstrate to have acquired the proper scientific terms and notions in order to critically and autonomously evaluate the biochemical processes of life
-Constitutive elements of the living matter: polymeric structure of the biological macromolecules Organic chemistry notions: carbon atom properties; hybrid orbitals; organic compounds classification: functional groups; hydrocarbons; alcohols, ethers, thiols, amines, aldehydes and ketones; carboxylic acids, esters, anhydrides.
- Structure and function of proteins: amino acids; peptide bond; structural levels of proteins; fibrous proteins and globular proteins; hemoglobin and myoglobin; hemoglobin variants; classification, function and regulation of enzymes.
- Bioenergetics: metabolism, chemical transformations in the cell; thermodynamics; ATP as energy exchanger; oxidation/reductions.
- Structure and metabolism of carbohydrates; mono- and disaccharides; polysaccharides. Glycolysis and its regulation. Alcoholic and lactic fermentation. Gluconeogenesis. Penthose phosphate pathway. structure, function and metabolism of glycogen..
- AcetylCoA. Citric acid cycle; electron transport chain and oxidative phosphorylation; ATP synthesis.
- Structure and metabolism of lipids: structural lipids and biological membranes; lipids transport; lipids digestion and fatty acids beta-oxidation; hints on fatty acids biosynthesis
- Amino acid metabolism; transamination and oxidative deamination; urea cycle; metabolism of the carbon chain.
The lessons will be delivered in dual mode - face to face and remotely. The material of the lessons will be available in the Moodle space.
|Bertoldi, Colombo, Magni, Marin, Palestini||Chimica e Biochimica||EdiSES||2015||978-88-7959-878-1|
|David L Nelson, Michael M Cox||Introduzione alla Biochimica del Lehninger||Zanichelli||2018|
|P.C. CHAMPE, R.A. HAEVEY, D.R. FERRIER||Le basi della biochimica||Zanichelli||2015|
To pass the Biochemistry module test the students must demonstrate an appropriate understanding of the basic concepts of biochemistry, from biological macromolecules to metabolic transformations. Furthermore, they must show the capability to expose their reasoning in a critical and precise manner and using an appropriate scientific language.
The exam consists of a written test, structured with 20 multiple choice questions.
The final score will be expressed in thirty's (/30). The examination will be validated with a minimum score of 18/30.