Master's degree in Sport Science and Physical Performance

Molecular adaptations to exercise and hypoxia

Course code
4S007458
Name of lecturers
Stefano Augusto Maria Biressi, Manuela Basso
Coordinator
Stefano Augusto Maria Biressi
Number of ECTS credits allocated
6
Academic sector
BIO/11 - MOLECULAR BIOLOGY
Language of instruction
Italian
Location
ROVERETO
Period
2° semestre motorie dal Mar 1, 2021 al May 31, 2021.

Lesson timetable

Go to lesson schedule

Learning outcomes

The course provides students with the fundamental concepts for the comprehension of molecular mechanisms operating at the cellular and tissue level in response to physical exercise and hypoxia.
At the end of this course the students will be able to:
1. comprehensively describe the adaptive responses to exercise and hypoxia;
2. fully understand the main cellular responses operating in the context of adaptation;
3. explain in depth the molecular mechanisms underlying paradigmatic adaptive responses;
4. integrate molecular, cellular and systemic mechanisms of adaptation;
5. critically analyze the acquired knowledge in the physiopathological and sports context
The course provides students with the fundamental concepts for the comprehension of molecular mechanisms operating at the cellular and tissue level in response to physical exercise and hypoxia.
At the end of this course the students will be able to:
1. comprehensively describe the adaptive responses to exercise and hypoxia;
2. fully understand the main cellular responses operating in the context of adaptation;
3. explain in depth the molecular mechanisms underlying paradigmatic adaptive responses;
4. integrate molecular, cellular and systemic mechanisms of adaptation;
5. critically analyze the acquired knowledge in the physiopathological and sports context
The course provides students with the fundamental concepts for the comprehension of molecular mechanisms operating at the cellular and tissue level in response to physical exercise and hypoxia.
At the end of this course the students will be able to:
1. comprehensively describe the adaptive responses to exercise and hypoxia;
2. fully understand the main cellular responses operating in the context of adaptation;
3. explain in depth the molecular mechanisms underlying paradigmatic adaptive responses;
4. integrate molecular, cellular and systemic mechanisms of adaptation;
5. critically analyze the acquired knowledge in the physiopathological and sports context

Syllabus

The course will be divided into two modules in which the following topics will be discussed:
1. Adaptative responses to the exercise:
- The integrated response to the exercise;
- Exercise and energy metabolism;
- Exercise-induced muscular hypertrophy: molecular signaling pathways involved, transcriptional mechanisms and control of protein synthesis;
- Stem cells and adaptive muscle response;
- Myokines and exercise;
- Exercise and brain.
2. Adaptive responses to hypoxia:
- Cellular and molecular mechanisms of oxygen sensing;
- Cellular and molecular responses to hypoxia: transcriptional mechanisms and control of protein synthesis;
- Epigenetic response to hypoxia;
- Muscle response to hypoxia: implications of physical exercise;
- Chronic and acute Hypoxia;
- Human evolution in altitude;
- Hints to molecular mechanisms of doping
-Hypoxia and apnea.


Lessons consist of frontal lectures (with slides) including group discussions of experimental evidence to support the illustrated concepts. The lessons will be held in Italian. The reference material will be partially in English. In addition to slides, the student may make use of scientific articles that will be indicated and the following texts:
1. Zierath J.R., Joyner M.J., Hawley J.A. (2017). The Biology of Exercise COLD SPRING HARBOR LABORATORY PRESS
2. Swenson E.R., Bartsch P. (2014). High Altitude: Human Adaptation to Hypoxia. Springer.
3. Speigelman B. (2017). Hormones, Metabolism asnd the Benefits of Exercise. Springer.
4. Roach R.C., Wagner P.D., Hackett P.H. (2016). Hypoxia: Translation in Progress. Springer.

Assessment methods and criteria

The objective of the exam consists in verifying the level of achievement of the previously indicated training objectives.
The exam consists of an oral interview with the teachers in which questions addressed in the course will be discussed.





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