|Teaching is organised as follows:|
|Unit||Credits||Academic sector||Period||Academic staff|
|FISICA APPLICATA||2||FIS/07-APPLIED PHYSICS||FISIO ROV 1^ ANNO - 1^ SEMESTRE||
|STATISTICA DESCRITTIVA||1||MED/01-MEDICAL STATISTICS||FISIO ROV 1^ ANNO - 1^ SEMESTRE||
|BIOLOGIA APPLICATA||2||BIO/13-EXPERIMENTAL BIOLOGY||Lezioni 1 Anno 1 semestre CLID ROV||
PREPARATORY CHEMISTRY (several notions are included in the basic knowledge required). 1. Atomic structure and periodic properties of the elements: matter composition, atom, atomic particles; atomic theory; quantum numbers, and orbitals; electronic configuration, periodic table and chemical reactivity of the elements; electronic affinity, electronegativity. 2. The chemical bond: molecules and ions; ionic and covalent bond; intermolecular forces; hydrogen bond. 3. Solutions and acid-base reactions: concentration of the solutions, acid-base theories of Arrhenius and Brőnsted-Lowry; hydracids, hydroxides, oxyacids; acid-base reactions; pH and buffer solutions. 4. Organic chemistry notions: carbon atom properties; hybrid orbitals; organic compounds classification: functional groups; hydrocarbons; alcohols, ethers, thiols, amines, aldehydes and ketones; carboxylic acids, esters, anhydrides. BIOCHEMISTRY 1. Constitutive elements of the living matter: polymeric structure of the biological macromolecules. 2. Protein structure and function: aminoacid classification, buffering power, peptide bond, levels of protein structure; fibrous and globular proteins; hemoglobin and myoglobin: structure, function, factors influencing the oxygen bond; hemoglobin variants; enzymes: classification, role in the chemical reactions, regulation of the enzymatic activity. 3. Vitamins: hydro- and lypo-soluble vitamins; co-enzymes. 4. Bio-energetics: metabolism; chemical transformations in the cell; spontaneous and non-spontaneous reactions of the metabolic reactions; ATP as “energy exchange coin”; biologically relevant redox reactions. 5. Carbohydrates structure and metabolism: mono- and disaccharides; polysaccharides; glycoconjugates; glycolysis and its regulation; gluconeogenesis; hints of the penthose phosphate pathway; synthesis of the glycogen. 6. Citric acid cycle and oxidative phosphorylation: mitochondria; acetyl-CoA synthesis; citric acid cycle control; respiratory chain and electron transport; ATP synthesis. 7. Lipids structure and metabolism: structural lipids and biological membranes; cholesterol; stock-reserve lipids; lipids digestion and fatty acid β-oxydation; keton bodies formation; hints of fatty acids biosynthesis. 8. Aminoacid metabolism: hints of gluco- and keto-forming aminoacids; transamination and oxidative deamination; the urea cycle. Frontal teaching is the exclusive method adopted in this Course.
MM: FISICA APPLICATA
Physical quantities and their measurement. Definition of a physical quantity. Unit consistency and conversions. Standards and units. Uncertainty and significant figures. The foundation of classical mechanics. Forces and motion. Newton’s laws of motion and their application. Motion description: displacement, velocity and acceleration. Work and kinetic energy. Potential energy and energy conservation. Momentum. Torque and angular momentum. Biomechanics. Lever systems in the human body. Equilibrium in the human body. Elements of mechanics of movement.
MM: STATISTICA MEDICA
• Use of statistics in health data • Collection and presentation of data • Measurement procedure and Variable types • Precision and accuracy of a measurement procedure • Tables 1 and 2 entries • Absolute and relative frequencies • Cumulative frequencies • Graphical representation of the data • Position and dispersion measures • Mode • Quantiles and median • Simple and weighted mean • Range and standard deviation • Coefficient of variation • Introduction to probability • Definition of probability • Rule of addition and multiplication • Independent and conditional probability • Introduction to statistical inference • The concept of statistical inference • Inference techniques • Binomial and Gauss distribution • confidence intervals • Hypothesis testing • Diagnostic and screening test • Sensitivity, specificity, positive predictive value of screening
MM: BIOLOGIA APPLICATA
• Characteristics of the living beings
• Chemistry of living organisms and biological molecules
• prokaryotic and eukaryotic cell: organization of the cell; internal membranes and compartmentalization; organelles, characteristics and functions: nucleus, ribosomes, RER, REL, Golgi, lysosomes, peroxisomes, cytoskeleton, cell wall, extracellular matrix. Animal and plant cells. Mitochondria and plastids (chloroplasts, amyloplasts, chromoplasts) and endosymbiont theory.
• Biological membranes: structure and proposed models; passage of materials across cell membranes: passive transport (facilitated diffusion and simple), osmosis, directly and indirectly active transport, co-transport. Exocytosis and endocytosis. Anchoring, tight and gap cell junctions in animal and plant cells.
• Cell communication: types of cellular communication: endocrine, paracrine, autocrine and iuxtacrine. Sending and receiving the signal.
• Organization of DNA in chromosomes, mitosis and meiosis. DNA and proteins, nucleosomes, heterochromatin, euchromatin, chromosome condensation. The cell cycle and its regulation. Mitosis, meiosis and sexual reproduction
• DNA and its role in heredity. DNA structure and replication.
• Gene expression: transcription, genetic code and translation. Gene definition.
• DNA mutations and mutagenesis
• Hereditary character transmission and Mendel’s laws; definition of phenotype, genotype, locus, gene, dominant and recessive allele, homozygosity and heterozygosity. Segregation and independent assortment. Independence and association. Crossing-over and recombination. Genetic determination of sex. Gene interactions. Incomplete dominance, condominance, multiple alleles, epistasis and polygeny.
• The human genome: karyotype analysis and pedigrees; autosomal recessive, autosomal dominant, X-linked diseases.
Attendance to lessons is mandatory.
Teaching methods consist of frontal lessons. In addition to the suggested texts, additional didactic supports are offered on the e-learning platform of the course.
Students can make an appointment directly with the teacher every time they need it throughout the academic year, by email.
Students are invited to choose a book among those indicated.
Goal of the exam for the course of Propaedeutic physical and biological sciences: to verify students' advanced comprehension of the whole program topics and their capability to expose their reasoning in a critical and precise manner using an appropriate scientific terms.
6 examination sessions are foreseen in the whole Academic Year: 2 in the Winter Session after the Course ending, 2 in the Summer Session, and 2 in the Autumn session.
Students will undertake all modules if they have attended at least 75% of the frontal teaching activity of the entire Course; further information about exam organization is available in each module form.
The final mark (/out of 30) will derive from the evaluation of the 4 modules. Students will pass the examination if the overall rating of all modules, based on the weighted average of credits, is greater than or equal to 18/30. Students can retire or refuse the proposed mark.
Students, who do not pass all the 4 exam modules in the same session, will only have to cover the missing/insufficient part in one of the subsequent sessions, if only within the extra winter session of the next Academic Year. From the next summer session, students will need to take all the 4 modules.
|Luciano BINAGLIA, Bruno GIARDINA||CHIMICA e PROPEDEUTICA BIOCHIMICA (con CD-ROM)||Ediz. Mc Graw-Hill|
|Solomon, Martin, Martin, Berg||Elementi di Biologia (Edizione 7)||EdiSES||2017||978-88-7959-938-2|
|Raven, Johnson, Mason, Losos, Singer||Elementi di biologia e genetica (Edizione 2)||Piccin||2019|
|Sadava, Hillis, Craig Heller, Hacker||Elementi di Biologia e Genetica (Edizione 5)||Zanichelli||2019|
|Jekel JF, Katz DL, Elmore JG, Wild DMG||Epidemiologia, Biostatistica e Medicina Preventiva||Elsevier-Masson||2009|
|D. Voet, J. G. Voet, C.W. Pratt||Fondamenti di Biochimica (Edizione 4)||Zanichelli||2017||9788808420961|
|David L Nelson, Michael M Cox||I principi di biochimica di Lehninger (Edizione 7)||Zanichelli||9788808920690|
|Armitage P, Berry G||Statistica medica. Metodi statistici per la ricerca in medicina (Edizione 3)||McGraw-Hill Libri Italia, Milano||1996|
|Glantz SA||Statistica per Discipline Biomediche (Edizione 6)||McGraw-Hill||2007||9788838639258|
|Paul Davidovits||Fisica per le professioni sanitarie||UTET Università||2015||8860084490|