Combined Bachelor's + Master's degree in Medicine and Surgery

Stem cell transplantation: biological and clinical issues  (Corso Elettivo)

Course code
Name of lecturer
Mauro Krampera
Mauro Krampera
Number of ECTS credits allocated
Academic sector
Language of instruction
1° semestre dal Oct 1, 2020 al Dec 23, 2020.

Lesson timetable

Go to lesson schedule

Learning outcomes

The course aims at giving a general overview on biological features and clinical application of hematopoietic and non-hematopoietic stem cell transplantation and regenerative medicine


1) Normal bone marrow: biological bases of hematopoietic and non-hematopoietic stem cell transplantation
2) Stem cell manipulation: technical and ethical issues
3) Immunobiology of hematopoietic stem cell transplantation
a) HLA restriction and antigen presentation
b) Immune response activation, costimulation and expansion
c) Cytokine network
4) Transplant-related immunological phenomena
a) Graft-versus-Host (GvHD)
b) Graft-versus-leukaemia (GvL)
c) Host-versus-Graft (HvG)
5) Hematopoietic stem cell transplantation procedure
6) Non-hematopoietic stem cell transplantation: new frontiers in Regenerative Medicine

Reference books
Author Title Publisher Year ISBN Note
Gian Paolo Bagnara Cellule Staminali (Edizione 2) Esculapio 2013 978-88-7488-997-6
Robert Lanza & Anthony Atala Essentials of Stem Cell Biology (Edizione 3) Elsevier Scienza Publishing Fumetto INC International Concepts   9780124095038

Assessment methods and criteria


DATE: MON 26 Oct 2020, WED 28 Oct 2020, MON 2 Nov 2020, WED 4 Nov 2020, h 17.30 - 19:30

NOTE: attendance of 3 out of 4 lessons is required for credits

Location: ONLINE LESSON VIA ZOOM (an email with the link will be sent to all subscribers 15 minutes before the start of the lesson). Credits will be given only to those who have attended at least 3 out of 4 lessons. Attendance will be recorded at each lesson, during which each student must always have the video camera on.

The course is specifically dedicated to 4th-5th-6th year students of Medicine.

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