Biomolecular fondamentals of life - BIOCHIMICA
To show the organization of the course that includes this module, follow this link 
Course organization
To transmit the main chemical principles to allow comprehension of the mechanisms that control matter interaction. To explain macromolecules organization and the principle of metabolism. To understand factors that regulate the main metabolic pathways. Emphasis will be on physiological and pathological processes associated to the main biochemical functions.
Chemistry
The matter: atoms, molecules.
Atomic organization: atomic orbitals, energy levels
Periodic table of the elements
Chemical bound: covalent, ionic. Week interactions: hydrogen bond, van der Waals, hydrophobic interaction.
Molecules: water. Properties and interactions in water.
Solutions: definitions and concentrations (Molarity), osmosis.
Buffer, pH.
Chemical reactions: red/ox.
Thermodynamic: Free energy (G), energetic potential of ATP, coupled reactions.
Biochemistry
Proteins: amino acids, peptide bound. Protein structures.
Post translational modifications. Quality control for secreted proteins.
Enzymes: kinetic, mechanism of action. Enzymatic inhibition. Allosteric regulation.
Nucleic acids: nucleotides, DNA, RNA
Sugars: simple and complex sugars. sugar bond, polysaccharides (starch and glycogen).
Glycoproteins: blood groups.
Membranes: properties, phospholipids, double layer.
Lipids: fatty acids, cholesterol.
Metabolism.
general principles, regulations, hormones, vitamins.
Sugar metabolism: glycolysis, regulations, alcohol fermentation, lactic fermentation. Pentose cycle.
Citric acid cycle: oxidative phosphorylation, ATP synthase
Gluconeogenesis.
Fatty acid metabolism: fatty acid digestion, beta oxidation, ketone bodies.
Fatty acid synthesis
Protein metabolism: transamination. Urea cycle.
Protein biosynthesis.
| Reference books | |||||
| Author | Title | Publisher | Year | ISBN | Note |
| Terry A. Brown | conoscere la biochimica (Edizione 1) | Zanichelli ed., Bologna | 2018 | ||
| David L Nelson, Michael Cox | introduzione alla biochimica di Lehninger (Edizione 4) | Zanichelli ed., Bologna | 2011 | ||
Assessment for learning will be through a written multiple choice. 20 questions in each test. Test is formulated by an automated system by the "Centro docimologico di Ateneo". Basically, questions are randomly chosen from a database made by the teacher. Questions are randomly mixed in each test. A question and an answer sheet are nominated for each student. Answer sheet are automatically read by the system and results are sent to the teacher.
© 2002 - 2021
Verona University
Via dell'Artigliere 8, 37129 Verona |
P. I.V.A. 01541040232 |
C. FISCALE 93009870234
Statistics
|
Credits
