# Combined Bachelor's + Master's degree in Medicine and Surgery

## Combined Bachelor's + Master's degree in Medicine and Surgery

### Physics-Medical statistics - STATISTICA MEDICA (2019/2020)

Course code
4S02595
Credits
6
MED/01 - MEDICAL STATISTICS
Language of instruction
Italian
Location
VERONA

 Teaching is organised as follows: Activity Credits Period Academic staff Esercitazioni di Statistica Medica 1 1° semestre Giuseppe Verlato Lezioni di Statistica Medica 5 1° semestre Giuseppe Verlato

## Learning outcomes

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MM: Esercitazioni di Statistica Medica
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Students will use a spreadsheet (Excel) to compute simple statistics.
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MM: Lezioni di Statistica Medica
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OBJECTIVES The course is aimed at presenting basic principles of medical statistics, necessary to study groups of individuals by taking into account inter-individual variability. In particular, the medical student will learn to: 1. Create and interpret a frequency table, starting from individual data 2. Represent data pertaining to a biological phenomenon with adequate graphics 3. Compute percentiles (or other quantiles) of a biological variable 4. Esitmate the relative risk associated with an exposure 5. Estimate sensitivity, specificity, positive and negative predictive values of a diagnostic procedure 6. Compute confidence intervals for means and proportions 7. Perform a statistical test to evaluate significance of differences between two means or two proportions. 8. Estimate the relation between two quantitative variables by a linear regression model

## Syllabus

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MM: Esercitazioni di Statistica Medica
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Practical exercises dealing with the theoretical program will be performed.
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MM: Lezioni di Statistica Medica
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SYLLABUS The following topics will be addressed: 1. Measurements performed in biomedicine: precision, accuracy, repeatability and validity. 2. Basic statistical methods to describe, interpret and present quantitative information collected on groups of individuals or other statistical units. 3. Probability: definitions, basic rules to compute probabilities and expected events. 4. Evaluation of a screening procedure when a gold standard is available: sensitivity, specificity, positive and negative predictive values, positive and negative likelihood ratio. Intra-rater and inter-rater agreement. 5. Main probabilistic models, useful to approximate the distribution of a biological variables within a population (binomial and gaussian distributions). 6. Basic design in observational and experimental research: random sampling and randomization. 7. Main inferential methods: confidence intervals to estimate parameters, and hypothesis testing to base decisions on experimental/observational evidence. 8. Basic concepts of multivariable statistical analysis: multiple linear regression to study quantitative outcomes, logistic model to study dichotomous outcomes, and Cox model to study survival. 9. Evidence-Based Medicine; systematic reviews and meta-analyses.

## Assessment methods and criteria

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MM: Esercitazioni di Statistica Medica
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In the second part of the exam students will have to solve problems of inferential statistics, which will require to compute confidence intervals and/or to perform simple statistical tests. For this purpose, students will be enabled to use a computer equipped with a spreadsheet.
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MM: Lezioni di Statistica Medica
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TYPE OF EXAMS A written exam will be performed in the computer lab. In the first part, students will have to answer about 30 multiple choice questions with 5-8 possible answers.

 Reference books Activity Author Title Publisher Year ISBN Note Esercitazioni di Statistica Medica Verlato G, Zanolin ME Esercizi di Statistica Medica, Informatica ed Epidemiologia Libreria Cortina Editrice, Verona 2000 Lezioni di Statistica Medica Daniel WW, Cross CL Biostatistica (Edizione 3) Edises 2019 libro più adatto al corso di Statistica Medica most appropriate book for the course of Medical Statistics Lezioni di Statistica Medica Norman G, Streiner D Biostatistica: quello che avreste voluto sapere… (Edizione 2) Casa Editrice Ambrosiana, Milano 2015 Lezioni di Statistica Medica Swinscow TDV, Campbell MJ Le basi della Statistica per scienze bio-mediche Edizioni Minerva Medica S.p.A., Torino 2004 libro sintetico Lezioni di Statistica Medica Bland M Statistica Medica APOGEO, Milano 2009 9788850327386

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