Bachelor's degree in Speech and Language Therapy (to qualify as a speech and language therapist)

Pathophysiological science (2019/2020)

Course code
Carlo Laudanna

Teaching is organised as follows:
Unit Credits Academic sector Period Academic staff

Learning outcomes

Illustrate the fundamental concepts of aetiology and pathogenesis and the links between the clinical manifestations of diseases and the mechanisms underlying them. INTERNAL MEDICINE MODULE Training objectives: The course aims to introduce the physiopathological mechanisms responsible for the main alterations of homeostatic systems of the organism, the functional consequences detectable on various organs and systems, the compensatory mechanisms activated following these alterations. MODULE GENERAL PATHOLOGY Educational objectives: The course will develop some topics of General Pathology preparatory to understanding the basic mechanisms of diseases. General Pathology is at a critical point, at the crossroads between basic and clinical science. The course therefore aims to establish the essential links between clinical manifestations and fundamental mechanisms, facilitating the understanding of the conceptual basis of the disease.


The program in brief
They will be explained: The general concepts of illness, disease and etio-pathology; the cell-based disease; oncology elements; immunity and inflammation

Detailed program

1) Generalities

a) Introduction to general pathology: fields and discipline purposes
b) The disease: definition; causes (determinants, adjuvants, occasional); pathogenesis; course (recurrence, relapse); outcomes (healing, chronic, death); diagnosis (signs and physical examination, symptoms and medical history).

2) Cell pathology

a) General concepts: the disease as the expression of cell damage?

b) Degenerative changes of the cells:
Causes (genetic, nutritional, from chemical, physical, from lack of oxygen, by living agents).
reversible cell damage, irreversible cell death. morphological cell changes related to the damage: various aspects of degeneration and necrosis

c) Modifications to steady-state cell:
stationary phones were molecular changes (hypertrophy, atrophy, atrophy) and their causes
cellular changes (hyperplasia, hypoplasia, aplasia) and their causes

d) Alterations of cellular differentiation processes:
Metaplasia, anaplasia, dysplasia

3) Oncology

Definition of neoplastic cells, benign and malignant tumors, Natural history of cancer: advancement, growth, progress, general effects on body. Metastasis

4) Inflammation

a) General concepts: utility of the inflammatory process
b) Acute inflammation: local and general manifestations of inflammation; causes; pathogenetic mechanisms (vascular component, the white blood cell component and the chemical mediators). The exudate and types of inflammation (erythema, serous, catarrhal, purulent, fibrinous, hemorrhagic, necrotizing). The consequences on 'body (abscess, phlegmon, fistula, adhesion, synechiae, payments).
c) Chronic inflammation: Causes; pathogenetic mechanisms; granuloma and granulomatous diseases.

Assessment methods and criteria

Written with multiple answers questions

Reference books
Author Title Publisher Year ISBN Note
Robbins e Cotran Le basi patologiche delle malattie (due volumi) Elsevier 2010
Pontieri GM Patologia e Fisiopatologia Generale Piccin Editore, Padova 2002
Giuseppe Pontieri Elementi di fisiopatologia generale per corsi di laurea in professioni sanitarie (Edizione 3) Piccin 2012
Pontieri GM Patologia e Fisiopatologia Generale per i corsi di laurea in professioni sanitarie (ristampa aggiornata) Edizioni Piccin, Padova 2007
RUBIN ET AL. Patologia. Fondamenti clinicopatologici in medicina Casa Editrice Ambrosiana 2006

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