Combined Bachelor's + Master's degree in Medicine and Surgery

Stem cell transplantation: biological and clinical issues  (Corso Elettivo)

Course code
Name of lecturer
Mauro Krampera
Mauro Krampera
Number of ECTS credits allocated
Academic sector
Language of instruction
1° semestre dal Sep 30, 2019 al Jan 10, 2020.

Lesson timetable

Go to lesson schedule

Learning outcomes

The course aims at giving a general overview on biological features and clinical application of hematopoietic and non-hematopoietic stem cell transplantation and regenerative medicine


1) Normal bone marrow: biological bases of hematopoietic and non-hematopoietic stem cell transplantation
2) Stem cell manipulation: technical and ethical issues
3) Immunobiology of hematopoietic stem cell transplantation
a) HLA restriction and antigen presentation
b) Immune response activation, costimulation and expansion
c) Cytokine network
4) Transplant-related immunological phenomena
a) Graft-versus-Host (GvHD)
b) Graft-versus-leukaemia (GvL)
c) Host-versus-Graft (HvG)
5) Hematopoietic stem cell transplantation procedure
6) Non-hematopoietic stem cell transplantation: new frontiers in Regenerative Medicine

Reference books
Author Title Publisher Year ISBN Note
Gian Paolo Bagnara Cellule Staminali (Edizione 2) Esculapio 2013 978-88-7488-997-6
Robert Lanza & Anthony Atala Essentials of Stem Cell Biology (Edizione 3) Elsevier Scienza Publishing Fumetto INC International Concepts   9780124095038
S. Tura LEZIONI DI EMATOLOGIA 6° edizione - Società Editrice Esculapio, Bologna 2015
Paolo Corradini - Robin Foà Manuale di ematologia Minerva Medica 2014 8877118164

Assessment methods and criteria


DATE: MON 28 Oct 2019, THU 31 Oct 2019, MON 4 Nov 2019, WED 6 Nov 2019, h 17.30 - 19:30

NOTE: attendance of 3 out of 4 lessons is required for credits

Location: TBD

The course is specifically dedicated to 4th-5th-6th year students of Medicine.

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