Bachelor's degree in Nursing (to qualify as a nurse) (Legnago)

Pathophysiology applied at Nursing - FARMACOLOGIA GENERALE

Course code
Name of lecturer
Laura Cuzzolin
Number of ECTS credits allocated
Academic sector
Language of instruction
INF LE - 1° anno 2° sem dal Feb 1, 2019 al Apr 10, 2019.

To show the organization of the course that includes this module, follow this link * Course organization

Lesson timetable

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Learning outcomes

The Course is targeted to give to the student basic knowledge and methodological instruments required to do nursing service in the management and monitoring of pharmacological therapies. The Course also covers the study of basic principles of pharmacology, in particular pharmacokinetic and pharmacodynamic mechanisms, and introduces the student to the understanding and assessment of the benefits and risks of major therapeutic approaches.


Definition of drug, medicinal product, generic drug, biosimilar, galenic and magistral preparations.
Origin of drugs and the process of drug development.
The market of drugs in Italy.
Leaflet of a drug.
Off-label use.
International Classification System of drugs.
Defined Daily Dose (DDD).
Symptomatic, curative, preventive and substitutive drugs.
Different actions of drugs: systemic or local, direct or indirect, primary or secondary, collateral, early or late onset.
Pharmacokinetics: absorption (mechanisms, routes of administration, formulations), distribution (plasma protein binding, tissue vascularization, blood-brain barrier and placental transfer of drugs), biotransformation reactions and excretion of drugs.
Pharmacokinetic parameters: bioavailability, volume of distribution, elimination half-life,clearance.
Pharmacodynamics: general mechanisms of action, receptor definition, drug-receptor interaction,agonism and antagonism, affinity and intrinsic activity of drugs.
Clinical risks related to drug use: therapeutic errors and classification of adverse drug reactions.
Pharmacovigilance: spontaneous reporting and the role of nurse.
Drug dependence.
Embryo-fetal toxicity.
The concepts of risk/benefit and cost/benefit applied to drug treatments.
“Placebo” and “Compliance” definitions.
Dosage, maximum dose, effective dose, posology, therapeutic index.
Therapeutic plasma levels of drugs, peak concentrations, therapeutic range, accumulation, toxic concentrations.
Therapeutic drug monitoring.
Drug interactions.
Variability in drug response: therapeutic problems in neonates and children, elderly, patients with renal or hepatic insufficiency.
Antimicrobial therapy: selective toxicity, spectrum of action, bacteriostatic and bactericidal activity, microbial resistance. Pharmacological characteristics and adverse effects of the most important groups of antibiotics, antifungals and antivirals.
Non-steroidal antiinflammatory drugs and paracetamol.

Reference books
Author Title Publisher Year ISBN Note
Conforti A., Cuzzolin L., Leone R., Moretti U., Pignataro G., Taglialatela M., Vanzetta M. Farmacologia per le professioni sanitarie Idelson-Gnocchi Sorbona 2015 978-88-7947-592-1
Rossi F., Cuomo V., Riccardi C. Farmacologia per le professioni sanitarie (Edizione 1) Minerva Medica 2014 978-88-7711-787-8

Assessment methods and criteria

Learning evaluation of the topics related to general pharmacology is made inside the written exam of "Pathophysiology applied at Nursing": 15 questions with multiple-choice answers (2 correct between 5) or semi-structured are provided.


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