Combined Bachelor's + Master's degree in Medicine and Surgery

General and Clinical Pathophysiology - FISIOPATOLOGIA CLINICA

Course code
Name of lecturers
Cristiano Fava, Pietro Minuz, David Sacerdoti
Number of ECTS credits allocated
Academic sector
Language of instruction
Lezioni 1° semestre 2°- 6° anno, Lezioni 2° semestre 1°- 5° anno

To show the organization of the course that includes this module, follow this link * Course organization

Lesson timetable

Go to lesson schedule

Learning outcomes

Aim of the course is to present the pathophysiological mechanisms responsible for the main alterations of the homeostatic systems, functional consequences on various organs and systems, describe the compensation mechanisms that are activated as a result of these changes and how they may themselves be the pathophysiological mechanisms of disease.

The following topics will specifically be addressed:
1 alterations of fluid and electrolyte balance;
2 alterations of the acid-base balance;
3 alterations of renal function;
4 impairment of cardiac function;
5 regulation of vascular function and alterations in blood pressure homeostasis;
6 impaired respiratory function and hypoxia;
7 alterations of liver function;
8 disorders of haemostasis and thrombosis;
9 alteration of formation and propagation of cardiac electric impulse.


Causes and mechanisms of edema and ascites
Fluid loss through vomiting and diarrhea
Alterations of plasma hosmolarity
Hpo- and hyperkalemia
Acute and chronic renal failure
Tubulopathies, glomerulopathies
Pathophysiology and molecular basis of primary and secondary arterial hypertension and target organ damage
Heart failure,
Acute pulmonary edema,
Ischaemic heart disease
Pathophysiology of the respiratory system
Chronic respiratory failure acute respiratory Failure (ARDS)
Bronchial asthma chronic obstructive pulmonary disease (COPD), emphysema
Restrictive pulmonary disease
Pulmonary embolism
Cor pulmonale
Metabolic and respiratory alterations of the acid-base balance s
Acute and chronic adrenocortical insufficiency
Primary and secondary arterial hypertension
Pathophysiology of the shock
Metabolism and excretion of bilirubin
Liver cirrhosis
Disorders of haemostasis
Mechanisms of cardiac arrhythmias

Reference books
Author Title Publisher Year ISBN Note
Kathryn L. McCance, Sue E. Huether Fisiopatologia ed elementi di patologia generale (Edizione 7) Edra 2016 978-88-214-4143-1
Dennis Kasper, Anthony S. Fauci Harrison - Principi di Medicina Interna McGraw-Hill 2016
Albi, E., Amberi-Impiombato, F.S., Curcio F., Moncharmont, B., Palese, A. Le basi cellulari e molecolari delle malattie (Edizione 2019) Sorbona Idelson Gnocchi 2018 ISBN 978-88-7947-671-3
G. M. Pontieri,L. Frati,M.A. RUSSO Patologia Generale e Fisiopatologia Generale Tomo 2 (Edizione 5) PICCIN-NUOVA LIBRARIA 2015
Abul K. Abbas, J. C. Aster, Vinay Kumar Robbins. Fondamenti di patologia e di fisiopatologia (Edizione 9) Edra 2013

Assessment methods and criteria

Oral and unique. In principle, the student will be examined on four topics (3 of General Pathology, General Pathophysiology and Clinical Pathophysiology) on each of them a mark will be will given, used to calculate the arithmetic mean representing the final mark.


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