Combined Bachelor's + Master's degree in Medicine and Surgery

Combined Bachelor's + Master's degree in Medicine and Surgery

General and Clinical Pathophysiology - PATOLOGIA E FISIOPATOLOGIA GENERALE (2018/2019)

Course code
Academic sector
Language of instruction


Teaching is organised as follows:
Activity Credits Period Academic staff
Lezioni di Patologia Generale 13 Lezioni 1° semestre 2°- 6° anno, Lezioni 2° semestre 1°- 5° anno Marco Antonio Cassatella
Stefano Dusi
Claudio Sorio
Esercitazioni di Patologia generale 1 1°-5° anno: attività pratiche e tutoriali 2° semestre Stefano Dusi

Go to lesson schedule

Learning outcomes

The main task of the course is to examine molecular mechanisms responsible for cell and tissue damage and implicated in the host response to cell damage and in repair of tissue injury. In addition, the course addresses pathophysiological mechanisms at the basis of alterations of the host main homeostatic systems, compensation responses induced by these alterations and their potential significance as mechanisms of diseases.


MM: Lezioni di Patologia Generale
Detailed program of General Pathology - Basic concepts in pathology (health and disease, etiology and pathogenesis, omeostasis, functional reserve) - General classification of causes of diseases - Alterations of chomosome structure, gene mutations and molecular basis of genetic diseases - Alterations of membrane transport - Alterations of inter-cellular communication and membrane receptor function with reference to lipoprotein receptors and their role in the pathogenesis of atherosclerosis and pathology of adhesive interactions in the context of leukocyte recruitment, platelet aggregation, blood coagul ation and thrombosis - Alterations of signal transduction - Pathologies due to ethanol and other common chemical compounds - Mechanisms of reactive oxygen species formation and their role in cell pathology - Amyloidosis - Aging - Necrosis, apoptosis and nettosis - Isto-cytological properties of tumor cells - Properties of tumor cell growth and metastatization - Chemical carcinogenesis - Molecular basis of tumor cell transformation: DNA damage DNA mechanisms of repair - Oncogenes and tumor suppressor genes - Vascular alterations in acute inflammation - Mediators of inflammation - Leukocyte adhesion to the vascular wall, transmigration and movement - Mechanisms of innate immunity: phagocytosis, cytokine secretion, activation - Chronic inflammation - Tissue repair and fibrosis - Quantitative and qualitative alterations of leukocyte functions - Synopsis of blood cell pathology
MM: Esercitazioni di Patologia generale
Each group of students will examine by microscope 15 glass slides showing samples of pathological tissues (inflammatory, degenerative, neoplastic diseases)

Assessment methods and criteria

MM: Lezioni di Patologia Generale
Oral exam
MM: Esercitazioni di Patologia generale

Reference books
Activity Author Title Publisher Year ISBN Note
Lezioni di Patologia Generale Robbins e Cotran Le basi patologiche delle malattie (due volumi) Elsevier 2010
Lezioni di Patologia Generale L. Altucci, G. Berton, B. Moncharmont, L.A. Stivala Patologia Generale (Edizione 1) Idelson-Gnocchi 2019
Lezioni di Patologia Generale Pontieri-Russo-Frati Patologia Generale e Fisiopatologia Generale (Edizione 5) Piccin 2015
Esercitazioni di Patologia generale H.G. Burkitt, Stevens A., Lowe J.S., Young B Wheater ISTOPATOLOGIA ESSENZIALE (Edizione 3) Casa Editrice Ambrosiana 2002


© 2002 - 2020  Verona University
Via dell'Artigliere 8, 37129 Verona  |  P. I.V.A. 01541040232  |  C. FISCALE 93009870234
Statistics  |  Credits