Bachelor's degree in Nursing (to qualify as a nurse) (Vicenza)

Pathophysiology applied at Nursing - PATOLOGIA GENERALE

Course code
Name of lecturer
Claudio Sorio
Number of ECTS credits allocated
Academic sector
Language of instruction
INF VI - 1° anno 2° sem dal Feb 1, 2018 al Mar 29, 2018.

To show the organization of the course that includes this module, follow this link * Course organization

Lesson timetable

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Learning outcomes

At the end of the course the student is expected to address the following subjects:

• Etiopathogenesis of cell damage
• Causes of alteration of cell function (chemical, physical and biological)
• Etiopathogenesis of disease. Concept of homeostasis and its regulation
• Acute and chronic inflammation
• Immune system: cell components, their function and interaction
• Homeostasis of the immune response, transfusion and transplants
• Molecular and cellular basis of neoplastic transformation


Introduction to pathology
• Cell homeostasis and alterations at the cell and organism levels
• The concept of biochemical lesion and subcellular localization
• Alteration of cell homeostasis: adaptation, necrosis, apoptosis, restoration of cell damage
• Examples of cell adaptation: alterations of cells status and differentiation

Causes of disease and mechanisms of cell damage
• General classification of the causes of disease: genetic (example: cystic fibrosis), environmental, multifactorial (example: atherosclerosis), chemical (example: alcohol), radiation, free radicals
• Mechanisms of healing

Oedema: pathogenesis and classification

Introduction to immunology and immunological damage

• Innate and acquired immunity: description of leukocytes involved and general mechanisms
• General features: antigen presentation, lymphocyte subclasses, complement
• MHC ad transplants
• Blood groups
• Mechanisms of immuological damage: anafilaxis, complement activation, role of antibodies and Fc receptor, cell-dependent cytotoxicity

• Role of blood vessels in inflammation
• Cells involved in inflammation
• Classification of inflammatory response based on prevalent features: erithematous, serous, fibrinous, purulent, necrotic-haemorragic
• Differences among acute and chronic inflammation
• Cytokines and their role in the regulation of the inflammatory response


• Differences among benign and malign neoplasms
• Properties of neoplastic cells: growth, invasion and differentiation
• General classification: epithelial, mesenchimal, neuroectodermal and germinal, hemopoietc cells neoplasms
• Natural history of neoplasia: precancerous lesions, carcinoma in situ, metastasis. Preferential localization. TNM score.
• Molecular basis of neoplastic transformation: oncogenes and tumor suppressor genes. Mechanisms of activation/inhibition.
• Cancer etiology: physical, chemical and biological
• Mechanism of damage: compression, paraneoplastic syndromes, cachexia
• Cancer biomarkers and their clinical relevance

Reference books
Author Title Publisher Year ISBN Note
Giovanni M. Pontieri Patologia generale & fisiopatologia generale. Per i corsi di laurea in professioni sanitarie (Edizione 3) Piccin 2018 8829921424

Assessment methods and criteria

Quiz: multiple choices. Oral test for nursing science for the students that pass the written test. Oral exam at request or if deemed appropriate by the commission for the other themes.


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