Combined Bachelor's + Master's degree in Dentistry and Dental Prosthetics

General pathology and immunology - PATOLOGIA GENERALE

Course code
Name of lecturer
Flavia Bazzoni
Flavia Bazzoni
Number of ECTS credits allocated
Academic sector
Language of instruction
LEZIONI 2° SEMESTRE dal Feb 19, 2018 al Jun 1, 2018.

To show the organization of the course that includes this module, follow this link * Course organization

Lesson timetable

Go to lesson schedule

Learning outcomes

The basic aim of the course of General Pathology and Immunology are: (i) to acquire the conceptual and scientific tools to explain the causes and mechanisms of human disease and the role of the immune system; (ii) to examine molecular mechanisms responsible for cell and tissue damage and implicated in the host response to cell damage and in the repair of tissue injury. In addition, the course addresses pathophysiological mechanisms at the basis of alterations of the host main homeostatic systems, compensation responses induced by these alterations and their potential significance as mechanisms of diseases. Moreover, tumor eathiology, molecular mechanisms responsible of neoplastic transformation, development of primary tumors and metastasis, and the systemic consequences of tumor-related pathologies (paraneoplastic syndromes, chacexia) will be explored. Particular attention will be devoted to the acquisition of scientific terms used in pathology.


1. Introduction
General concepts

2. Cellular pathology: basic mechanisms of cellular damage; biochemical lesion.
Pathogenesis of hypoxia, ischemia and oxidative stress.
Oxygen radical-induced pathologies.
Pathogenesis of radiation damage.
Biological causes of diseases: general concepts of pathogenesis of infectious diseases. Endotoxins and exotoxins: physical-chemical features, biological effects, molecular basis.
Cellular death: necrosis. Serum markers of necrosis. Necrosis pathologist classification.

3. Introduction to the immune system: cellular composition and function.
The hematopoietic system: blood cell composition; hematocrit; leukocyte formula.
Functional and morphological features of leukocyte cell populations.
The reticulo-endothelial system.
Differentiation and maturation of the lymphoid and myeloid cell populations.
Innate and acquired immune responses: general concepts.
Inflammation: causes, cardinal signs, angiophlogosis and histoflogosis.
The vascular response. Exudate: features and functions.
The cellular response: leukocyte migration, rolling, activation, firm adhesion and diapedesis.
Adhesion molecules: selectins, integrins, immunoglobulins.
Chemotaxis and chemotactic factors.
Leukocyte effector mechanisms (phagocytosis, killing and degradation of phagocytosed microbes)
Defects of innate immune cells: LAD, CGD.
Chemical mediators and regulators of inflammation.
Coagulation; Complement; chinins, plasmin.
Cellular proinflammatory mediators: (i) preformed; (ii) newly synthesized (fast); (iii) newly synthesized (slow).
Cytokines: general concepts; cytokine families; physiological role; mechanisms of action.
Chemokines: C, CC, CXC, CX3C.
Proinflammatory cytokines: TNF alpha, IL-1, IL-6: producing cells, stimuli, biological role, local, systemic and pathologic effects.
Autoinflammatory syndromes: definition, causes, therapeutic strategies.
Inhibition of proinflammatory cytokines: IL-10 and IL-1ra. Anti-cytokine therapy in autoimmune diseases.
Cytokine response in sepsis and physical exercise.
Interferons: classes, producing cells, stimuli, biological and pathological role.
Systemic effects of inflammation.
Pathogenesis of septic shock.

4. Outcomes of acute inflammation.
Chronic inflammation. Granuloma.
Resolution: Regeneration and repair.

5. Genoma ed epigenoma.
The "Histone code".
Non-coding RNAs.
Apoptosi: estrinsic and intrinsic pathway.

6. Mechanisms regulating cellular differentiation and proliferation: pathological changes.
Metaplasia, dysplasia and neoplasia. Neoplasia (general concepts)
Morphological, molecular, metabolic, genetic and functional features of the neoplastic cell.
Cancer etiology and pathogenesis.
Cancer natural history.
Molecular bases of carcinogenesis: proto-oncogenes, oncogenes, tumor suppressor genes. Oncogenes classes: (i) growth factors (EGF); (ii) growth factor receptors (EGFR/ErbB, Her2 receptor/Neu); (III) signal transduction proteins (ras); (IV) nuclear transcription factors (myc); (V) chromatin-associate proteins; (VI) cell cycle control; (VII) microRNA; (VIII) pro and anti-apoptotic proteins (Bcl2).
Tumor suppressor genes: Cyclins, retinoblastoma, p53: physiologic and pathologic role.
The Knudson hypothesis.
Viral carcinogenesis.
Nomenclature. The TNM system.
Benign and malignant hematologic neoplasia.
Head and neck cancer.
Metastasis: molecular basis of metastasis generation ad progression.
Neoplastic cachexia and paraneoplastic syndromes.
Tumor immunology.

Reference books
Author Title Publisher Year ISBN Note
Mozzo Pierluigi Materiale didattico e informatico distribuito dal docente 2018

Assessment methods and criteria

Oral test.


© 2002 - 2020  Verona University
Via dell'Artigliere 8, 37129 Verona  |  P. I.V.A. 01541040232  |  C. FISCALE 93009870234
Statistics  |  Credits