Objectives of the course
• acquisition of the knowledge in fundamental biologic mechanisms regulating the immune system function for the defense against infections, as well as pathogenesis of hypersensibility, autoimmunity and immunodeficiency;
• understanding the main laboratory methods used by the immunologist and the immune pathologist;
Objectives of professional expertise
• overview on the immune system function, either in health or disease state;
• overview on the basics for the most common immune laboratory techniques, with the aim to understand: a) the results of laboratory analyses obtained through immunological techniques; b) previously occurred immune responses to infections; c) congenital or acquired immune dysfunctions; d) hypersensibility patterns; e) main autoimmune pathologies; f) immune strategies applied to allergy and immunodeficiency therapies; g) general principles of vaccine and immune suppression therapy; h) transplantation and tumor immunology.
Innate and acquired Immunity. Anatomy, cytology and biochemistry of the immune system: lymphoid organs, cells (lymphocytes, dendritic cells, macrophages, granulocytes, hemopoietic precursors), and molecules (immunoglobulins, T cell receptor, MHC molecules, co-stimulatory molecules). Cellular receptors of innate immunity, sensing of pathogen and damage patterns. Antigen processing and presentation. Cell-mediated and humoral immune response. The complement cascade. Cytokines, chemokines and cell-cooperation. Defense against infections. Immune tolerance. Hypersensibility reactions. Autoimmune diseases. Immunodeficiency. Immunity and tumors. Principles of immunotherapy. Immuno-hematology. Immunology of transplantation.
|Cellular and Molecular Immunology||A.K. ABBAS, A.H. LICHTMAN, S. PILLAI||2018|
|K. MURPHY, P. TRAVERS, M. WALPORT||Janeway’s Immunobiology||2017|
|PETER PARHAM||The immune system||2017|
Written test, based on questions with multiple choice answers., with eventual oral examination.