Laurea magistrale a ciclo unico in Medicina e chirurgia

Epigenomica e nutrizione: dai meccanismi molecolari alla malattia  (Corso Elettivo)

Codice insegnamento
DF-0022
Docente
Simonetta Friso
Coordinatore
Simonetta Friso
crediti
1
Settore disciplinare
MED/09 - MEDICINA INTERNA
Lingua di erogazione
Italiano
Periodo
Corsi elettivi 2° semestre dal 20-feb-2017 al 26-mag-2017.

Orario lezioni

Corsi elettivi 2° semestre

Non inserito.

Obiettivi formativi

In una moderna visione della medicina molecolare, i nutrienti non sono da intendersi solo come sostanze necessarie al mantenimento delle funzioni vitali dell’organismo umano ma piuttosto quali elementi fondamentali nel modulare l’espressione genica secondo interazioni genetico-nutrizionali in grado di regolare i processi fisiopatologici. Proponiamo pertanto un corso elettivo che affronti questo nuovo argomento di medicina clinico-molecolare che concerne il ruolo dei nutrienti nel modulare l’espressione genica attraverso meccanismi epigenetici quali, in particolare, la metilazione del DNA e le modificazioni istoniche post-trascrizionali. Questo corso ha lo scopo principale di fornire uno strumento di apprendimento di questa nuova frontiera della scienza medica rappresentata dall’epigenetica nonché di approfondire la conoscenza sui meccanismi di interazione tra genetica e nutrizione in processi fisiologici e patologici attraverso la modulazione di meccanismi epigenetici.

Programma

- Introduzione all’epigenetica
- Effetti dei nutrienti su metilazione del DNA e modificazioni istoniche
- Interazioni geni-nutrienti ed epigenetica: il modello di alcune patologie
- Metodiche di approccio allo studio dell’epigenetica e dell'epigenomica

Testi di riferimento
Autore Titolo Casa editrice Anno ISBN Note
Sang-Woon Choi, Simonetta Friso Nutrient-Gene Interactions in Cancer (Edizione 1) CRC Press,Taylor and Francis Group 2006 9780849332296 Features Provides the latest epidemiological evidence on the interactions between nutrients and gene polymorphisms affecting cancer development Describes interactions that affect colorectal, breast, lung, prostate, liver, and other gastroenterological cancers, as well as hematologic malignancies Gives an overview of nutrient-gene interaction mechanisms and explores specific biomarkers Offers striking examples of the interaction between genetics, epigenetics, and nutrition in many different types of cancer Summary The complete mapping of the human genome, along with the development of sophisticated molecular technologies, has accelerated research on the relationship between nutrients and genes. This has led to compelling evidence garnered from epidemiological and experimental observations supporting the idea that the interaction between nutrients and genes is one of the most important mechanisms influencing carcinogenesis. Nutrient-Gene Interactions in Cancer brings together leading authorities in the field who provide an overview and look specifically at the mechanisms known to underlie each nutrient and gene interaction. The book examines the multi-functional relationship linking nutrition and cancer development, including the complex role nutrients have in modulating cancer growth via interactions with specific genes, and the emerging new strategy for cancer chemoprevention that is based on a deepened understanding of this relationship. The authors also provide freshly illuminating information on many well-known interactions. The first part of the book includes chapters on the basic elements of biology and pathobiology of gene-nutrient interactions with a focus on mechanisms and biomarkers. This is followed by chapters, which detail specific gene-nutrient interactions, offering numerous examples supported by recent investigations. The final chapter looks to the future, considering the potential for further investigation by outlining new perspectives in this rapidly growing area of medical science. While this work is especially valuable to science investigators, it will also be of great interest to clinicians who manage cancer patients, in that it presents useful tools that advance the clinical value of gene-nutrient interaction research in medical nutrition and oncology.
Sang-Woon Choi and Simonetta Friso Nutrients and Epigenetics (Edizione 1) CRC Press,Taylor and Francis Group 2009 9781420063547 Features Presents research on the relationship between nutrition and epigenetics Describes how nutrients affect pathologic and physiologic processes Explains epigenetic phenomena including DNA methylation, histone modifications, and chromatin remodeling Proposes future direction for research and clinical implications involving nutrition and epigenetics Summary Explores the Newly Discovered Link Between Nutrition and Epigenetics Current research suggests that nutrients are more than just food components and that certain nutrients can impact the expression of genes that lead to the development of chronic diseases. With contributions from experts in both fields, Nutrients and Epigenetics examines the epigenetic phenomena and the fascinating implications of diet on this largely uncharted field. Generously laden with tables and illustrations, many in color, this book addresses how nutrients alter physiologic and pathologic processes in the human body through epigenetic changes without affecting the DNA sequence. It also explains the detailed molecular structures of epigenetic phenomena and closely examines the current knowledge surrounding the biology of aging and embryonic growth regulation. Assesses the Likelihood of Clinical Applicability In one single compendium, this resource delineates the nutritional factors that further much-studied aberrant epigenetic patterns, such as DNA methylation, histone modifications, and chromatin remodeling. The book spotlights the influence of nutrition on epigenetic gene regulation, opening the way for counteracting future disease processes associated with epigenetic phenomena—a step that could potentially change the face of disease prevention and development.

Modalità d'esame

IDONEITÀ SULLA BASE DELLA FREQUENZA e di test intermedi durante il corso

- Lunedì 20 febbraio, ore 17.30-19.00,
- Lunedì 27 febbraio, ore 17.30-19.00,
- Lunedì 6 marzo, ore 17.30-19.00,
- Lunedì 13 marzo, ore 17.30-19.00,

aula G lente didattica

Opinione studenti frequentanti - 2016/2017






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