Combined Bachelor's + Master's degree in Medicine and Surgery

General and Clinical Pathophysiology (2019/2020)

Course code
4S02598
Credits
19
Coordinator
Marco Antonio Cassatella

Teaching is organised as follows:
Unit Credits Academic sector Period Academic staff
PATOLOGIA E FISIOPATOLOGIA GENERALE 14 MED/04-EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY See the unit page See the unit page
FISIOPATOLOGIA CLINICA 5 MED/09-INTERNAL MEDICINE 1° semestre, 2° semestre 1°- 5° anno Cristiano Fava
Pietro Minuz
David Sacerdoti

Learning outcomes

The main task of the course is to examine molecular mechanisms responsible for cell and tissue damage and implicated in the host response to cell damage and in repair of tissue injury. In addition, the course addresses pathophysiological mechanisms at the basis of alterations of the host main homeostatic systems, compensation responses induced by these alterations and their potential significance as mechanisms of diseases.

Syllabus

Detailed program of General Pathology

- Basic concepts in pathology (health and disease, etiology and pathogenesis, omeostasis, functional reserve)
- General classification of causes of diseases
- Alterations of chomosome structure, gene mutations and molecular basis of genetic diseases
- Alterations of membrane transport
- Alterations of inter-cellular communication and membrane receptor function with reference to lipoprotein receptors and their role in the pathogenesis of atherosclerosis and pathology of adhesive interactions in the context of leukocyte recruitment, platelet aggregation, blood coagul ation and thrombosis
- Alterations of signal transduction
- Pathologies due to ethanol and other common chemical compounds
- Mechanisms of reactive oxygen species formation and their role in cell pathology
- Amyloidosis
- Aging
- Necrosis, apoptosis and nettosis
- Isto-cytological properties of tumor cells
- Properties of tumor cell growth and metastatization
- Chemical carcinogenesis
- Molecular basis of tumor cell transformation: DNA damage DNA mechanisms of repair
- Oncogenes and tumor suppressor genes
- Vascular alterations in acute inflammation
- Mediators of inflammation
- Leukocyte adhesion to the vascular wall, transmigration and movement
- Mechanisms of innate immunity: phagocytosis, cytokine secretion, activation
- Chronic inflammation
- Tissue repair and fibrosis
- Quantitative and qualitative alterations of leukocyte functions
- Synopsis of blood cell pathology

Module: FISIOPATOLOGIA CLINICA
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Assessment methods and criteria

Module: FISIOPATOLOGIA CLINICA
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Module: PATOLOGIA E FISIOPATOLOGIA GENERALE
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Reference books
Author Title Publisher Year ISBN Note
Cellular and Molecular Immunology A.K. ABBAS, A.H. LICHTMAN, S. PILLAI 2018
L. Altucci, G. Berton, B. Moncharmont, L.A. Stivala Patologia Generale (Edizione 1) Idelson-Gnocchi 2019
Rubin E. Patologia Generale Anatomia Patologica Piccin 2019
Pontieri G.M. Patologia generale e Fisiopatologia Generale (Edizione 6) Piccin 2019
Kumar V, Abbas AK, Aster JC Robbins Basic Pathology (Edizione 10) Elsevier 2018
Majno, Joris Cellule, tessuti, malattie Casa Editrice Ambrosiana 2009
Kathryn L. McCance, Sue E. Huether Fisiopatologia ed elementi di patologia generale (Edizione 7) Edra 2016 978-88-214-4143-1
Kasper Gl, et al. Harrison's Principles of Internal Medicine, 19th Edition, Mc Graw Hill, 2018
Albi, E., Amberi-Impiombato, F.S., Curcio F., Moncharmont, B., Palese, A. Le basi cellulari e molecolari delle malattie (Edizione 2019) Sorbona Idelson Gnocchi 2018 ISBN 978-88-7947-671-3
G. M. Pontieri,L. Frati,M.A. RUSSO Patologia Generale e Fisiopatologia Generale Tomo 2 (Edizione 5) PICCIN-NUOVA LIBRARIA 2015




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