Combined Bachelor's + Master's degree in Medicine and Surgery

Chemistry and Biological chemistry (2019/2020)

Course code
4S01134
Credits
15
Coordinator
Marta Palmieri

Teaching is organised as follows:
Unit Credits Academic sector Period Academic staff
CHIMICA BIOLOGICA 8 BIO/10-BIOCHEMISTRY 2° semestre 1°- 5° anno Marta Palmieri
CHIMICA E PROPEDEUTICA BIOCHIMICA 7 BIO/10-BIOCHEMISTRY 1° semestre Mariarita Bertoldi

Learning outcomes

Module of Chemistry and Biochemistry Propaedeutics The module of Chemistry and Biochemical Propaedeutics is preparatory to that of Biological Chemistry as it represents the element of connection between the fundamental knowledge of chemistry and the most strictly biochemical phenomena. The course describes: - the fundamentals of chemistry necessary for the knowledge of living matter and its transformations; - the structural chemistry of the components of living matter and the relationship between biological function and chemical structure; - stoichiometry and the mechanism of a large number of reactions; - the fundamental principles of thermodynamics; Training objectives: - to know the characteristics of elements and compounds and the principles that allow to understand their behaviour in biological systems; - to understand the reactivity of the different classes of organic compounds in order to know how to interpret the behaviour in biological systems; - being able to perform elementary calculations with regard to the quantitative aspects of chemistry applied to the Medical Sciences; - to acquire a solid chemical basis to be able to interpret at a molecular level the phenomena described by biochemistry; - to know the structure and function of proteins, carbohydrates and lipids; to understand the properties of enzymes, their reaction kinetics and catalytic mechanisms.

Module of Biological Chemistry Training objectives - to know how living beings synthesize and degrade carbohydrates, lipids, proteins, amino acids, nucleotides and other fundamental biological molecules; - to know the structure and function of vitamins and hormones; - to understand how the human body coordinates the thousands of reactions it catalyzes; - to understand the metabolic relationships between the various tissues and organs, as well as the main systems of intercellular communication; - to know particular topics of molecular and cellular biochemistry, such as oxygen transport, transport in biological membranes, signal transduction and the molecular mechanism of contraction; - to acquire useful information on the biochemical bases of diseases.

Syllabus

GENERAL CHEMISTRY
-Matter
- Chemical reactions and equations:
-Stoichiometriy
-Gas
-Thermochemistry
-Atom structure.
-More electronic devices
-The Periodic Character of Atomic Properties
- Chemical bonds
From atoms to molecules
- Weak intermolecular forces
-Solutions
- Chemical Equilibrium
- Reaction of acids and bases
-Thermodynamics
-Electrochemistry
-Chemical kinetics.

ORGANIC CHEMISTRY
-Carbon
-Hydrocarbons
-Benzene and aromatic compounds
-Stereoisomers: -Functional Groups and Definition of Families of Organic Compounds
-Bonds
-Organic reactions
-Organic macromolecules

BIOLOGICAL CHEMISTRY
-Proteins
-Enzymes
-Vitamins
-Lipids
-Carbohydrates
- Bioenergetics
- Glucid metabolism
- Lipid metabolism
- Protein metabolism
- Terminal metabolism
- Metabolic adjustment, tissue integration and signal transduction
- Nucleotide metabolism
- Vitamins

Assessment methods and criteria

The examination of the "Chemistry and Propedeutic Biochemistry" module is organized in written questions of stoichiometry, acid-base and oxidation reactions and an organic chemistry reaction mechanism. The oral examination, which can be accessed after passing the written questions, consists of a series of questions regarding the understanding of the topics of general chemistry, organic chemistry and propedeutics biochemistry carried out during the course.

The examination of the "Biological Chemistry" module consists of written questions with multiple responses, a description of biochemical reactions or metabolic pathways. The oral examination, which is accessible after passing the written questions, consists of an interview aimed at evaluating the student's ability to use chemical and biochemical knowledge for the interpretation of physiological and pathological phenomena in humans.

Reference books
Author Title Publisher Year ISBN Note
Catani et all Appunti di biochimica (Edizione 2) piccin 2017 978-88-299-2843-9
Mathews Biochimica Piccin 2014
Jeremy M Berg, John L Tymoczko, Lubert Stryer BIOCHIMICA (Edizione 7) Zanichelli 2012 9788808198730
Monica Stoppini, Vittorio Bellotti Biochimica applicata Edises 2012 9788879597135
Thomas M. Devlin Biochimica con aspetti clinici (Edizione 5) Edises 2013 9788879597807
Siliprandi - Tettamanti Biochimica Medica - Strutturale, metabolica e funzionale (Edizione 5) Piccin 2018 978-88-299-2791-3
Stefani M, Taddei N Chimica Biochimica e Biologia Applicata. Zanichelli ed., Bologna  
John R. Holum Elementi di chimica generale, organica e biologica. Zanichelli  
D. Voet, J. G. Voet, C.W. Pratt Fondamenti di Biochimica (Edizione 4) Zanichelli 2017 9788808420961
David L Nelson, Michael M Cox I principi di biochimica di Lehninger (Edizione 7) Zanichelli 2018 9788808920690
G. Meisenberg, W.H. Simmons Principi di Biochimica Medica Edizioni Minerva Medica 2013 978-88-7711-777-9
Garrett - Grisham Biochimica Piccin 2014




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