Combined Bachelor's + Master's degree in Medicine and Surgery

Systematic pathology I (2019/2020)

Course code
4S01150
Credits
22
Coordinator
Mauro Krampera

Teaching is organised as follows:
Unit Credits Academic sector Period Academic staff
ANATOMIA PATOLOGICA 1 1 MED/08-PATHOLOGY 1° semestre Matteo Brunelli
DERMATOLOGIA 3 MED/35-DERMATOLOGY AND VENEREAL DISEASES 1° semestre Giampiero Girolomoni
Paolo Gisondi
GASTROENTEROLOGIA 3 MED/12-GASTROENTEROLOGY 1° semestre Rachele Ciccocioppo
Luca Frulloni
EMATOLOGIA 3 MED/15-BLOOD DISEASES 1° semestre Mauro Krampera
Fabrizio Vinante
Carlo Visco
REUMATOLOGIA 3 MED/16-RHEUMATOLOGY 1° semestre Domenico Biasi
Davide Gatti
Maurizio Rossini
MALATTIE INFETTIVE 3 MED/17-INFECTIOUS DISEASES 1° semestre Evelina Tacconelli
DIDATTICA PRATICA DI EMATOLOGIA, GASTROENTEROLOGIA, MALATTIE INFETTIVE, REUMATOLOGIA, DERMATOLOGIA E TUTORIAL PROBLEM BASED LEARNING 6 NN-- See the unit page See the unit page

Learning outcomes

Medical students will be able to grasp basic knowledge related to epidemiology, classification, pathophysiology, methodological and diagnostic istopathological and clinical approaches, impact of treatment on natural history of main hematological, reumathological, allergic, gastroenterological, infectious and cutaneous disorders.

Syllabus

GASTROENTEROLOGY
Esophageal diseases
Gastric and duodenal diseases
Peptic ulcer
Bleeding of the upper and lower gastrointestinal tract
Maldigestion and malabsorption
Inflammatory bowel diseases
Poliposis and cancer of the colon
Irritable bowel syndrome
Diverticular disease
Acute and Chronic diarrhea
Acute and chronic liver disease
Liver cirrhosis
Biliary lithiasis
Pancreatic diseases

DERMATOLOGY
Basic principles of skin, mucous membranes and adnexal anatomy an physiology Specialistic methodology and semeiotic, primary cutaneous lesions. Pruritus Bacterial diseases (erysipelas, cellulitis, foruncle, impetigo, folliculitis, Gram- intertrigo, scarlet fever) Fungal diseases (dermatophytosis , pityriasis versicolor , candidosis) Viral diseases (herpes simplex, herpes zoster,Chickenpox, HPV diseases, molluscum contagiosum, hand-foot-mouth disease) Infestations: scabies, pediculosis, insect bites Acne vulgaris, rosacea Eczematous disease (atopic dermatitis, contact dermatitis , sebborrheic dermatites) Urticaria and angioedema Psoriasis Vesciculobullous disease(pemphigus, pemphigoid, dermatitis herpetiformis) Connective Tissue Diseases (Lupus erythematosus, systemic sclerosis, dermatomyositis), vascular disorders, erythema nodosum Drug reaction (esanthema, fixed eruption) Severe drug reaction (AGEP, Stevens-Johnson syndrome, Lyell syndrome) Cutaneous ulcers Vascular malformation and hemangiomas Benign epidermal tumors (sebborrheic keratosis, papillomatous lesions, fibrous lesion) Epithelial tumors(actinic keratosis, basal cell carcinoma, squamous cell carcinoma ) Kaposi sarcoma Cutaneous lymphomas Melanocytic lesions and melanoma Dermatologic therapy VENEREOLOGY Sexually trasmitted infections epidemiology and profilaxis Syphilis: clinical features, serologic tests and therapy Gonorrhea and non gonooccal urethritis HPV infection trasmitted disease Herpes genitalis Balanoposthitis, vulvovaginitis

HEMATOLOGY
- the blood (investigation methods, embryogenesis, hematopoiesis, hematocatheresis)
- anemias (classification, clinical features and differential diagnosis)
- approach to hematological malignancies
- acute leukemias
- myelodysplasia, secondary malignancies and treatment complications
- chronic myeloproliferative neoplasia
- chronic lymphoproliferative disorders
- monoclonal gammopathies, myeloma
- hemostasis disorders
- hematopoietic stem cell transplantation

REUMATOLOGY
- degenerative and inflammatory rheumatic diseases, with different diagnosis elements of rheumatoid arthritis, osteoarthritis, gout, calcinosis and spondyloarthritis
- multisystemic rheumatic diseases, in particular to connectivitis and vasculitis
- main degenerative bone diseases, both primary and secondary
- laboratory procedures and laboratory reports
- osteoarticular damages in x-ray images.

INFECTIOUS DISEASES
• Introduction to infectious diseases: differences between infection and infectious disease.
• Epidemiology, diagnosis, clinical presentation and treatment of HIV infection, AIDS and main opportunistic AIDS-related diseases.
• Respiratory infections: pneumonia, flu, pertussis and diphtheria.
• Pulmonary and extra-pulmonary tuberculosis.
• International traveler's infectious diseases.
• Mumps, infective esanatemias.
• Sepsis, endocarditis
• Gastroenteritis, infective intoxications and toxinfections.
• Encephalitis, meningitis and rabies.
• urinary tract infections
• TORCH complex infections
• viral hepatitis
• EBV and CMV infections
• Health-care associated infections
• Lyme disease, leptospirosis
• Malaria
• Brucellosis
• Tetanus, botulism

Assessment methods and criteria

ORAL EXAMINATION about at least two/three subjects dealing with the six disciplines of the Course (Pathology, Dermatology, Hematology, Gastroenterology, Infectious diseases, Rheumatology).
The final grade will be the arithmetic average of each examiner's marks.

Note: Students who register for the exam are invited to cancel their names from the appeals they do not participate in. If they cannot cancel, they must write an email to the course Coordinator as soon as possible. Those who do not cancel or do not notify the Coordinator will not be able to participate in the next call offered in the same session.

Reference books
Author Title Publisher Year ISBN Note
ALDO SCARPA, LUIGI RUCO ANATOMIA PATOLOGICA. LE BASI 1 UTET 2007 8802076561
J-H Saurat, E. Grosshans, P. Laugier, J-M Lachapelle Dermatologia e malattie sessualmente trasmesse Edra 2018 9788877119797
Claudio Ortolani DIAGNOSTICA CITOMETRICA DELLE NEOPLASIE EMATOLOGICHE (Edizione 1) Quattroventi 2002 9788839206206
C. Feliciani Guida Pratica di Dermatologia e Venereologia Piccin 2014
Dennis Kasper, Anthony S. Fauci Harrison - Principi di Medicina Interna McGraw-Hill 2016
S. Tura LEZIONI DI EMATOLOGIA 6° edizione - Società Editrice Esculapio, Bologna 2015
Castoldi G. e Liso V Malattie del sangue e degli organi emopoietici (Edizione 4) McGraw-Hill 2014
Esposito R, De Lalla F, Moroni M. Malattie Infettive. Milano, Masson Editore 2003
Paolo Corradini - Robin Foà Manuale di ematologia Minerva Medica 2014 8877118164 in corso di ristampa
UNIGASTRO Manuale di Gastroenterologia Editrice Gastroenterologica Italiana 2019 8849005636
Nino Basaglia Medicina Riabilitativa Idelson - Gnocchi 2009 9788879474917
Marcadante K.J, Kliegman R.M. et al. Nelson Essential of Pediatrics (Edizione 18) Elsevier 2015
Salaffi Fausto SEMEIOTICA REUMATOLOGICA. PARTE I – ARTO SUPERIORE (Edizione 1) Mattioli 1885 2015
Salaffi Fausto SEMEIOTICA REUMATOLOGICA. PARTE III – ARTO INFERIORE Mattioli 1885 2015
Salaffi Fausto SEMEIOTICA REUMATOLOGICA. PARTE SEMEIOTICA REUMATOLOGICA PARTE II – COLONNA VERTEBRALE E ARTICOLAZIONE TEMPORO-MANDIBOLARE Mattioli 1885 2015
Kumar –Cotran-Robbins Anatomia Patologica (Edizione 6) EMSI Editrice, Roma. 2015
Rubin E. Patologia Generale Anatomia Patologica Piccin 2019
Klaus Wolff, Richard Allen Johnson, Dick Suurmond Fitzpatrick Atlante di Dermatologia Clinica Mc Graw Hill 2014 9788829926664




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