Combined Bachelor's + Master's degree in Medicine and Surgery

Immunology

Course code
4S00179
Name of lecturer
Vincenzo Bronte
Coordinator
Vincenzo Bronte
Number of ECTS credits allocated
9
Academic sector
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY
Language of instruction
Italian
Period
2° semestre 1°- 5° anno dal Feb 17, 2020 al May 29, 2020.

Lesson timetable

Go to lesson schedule

Learning outcomes

Aims of the Immunology course are: acquisition of the knowledge of the fundamental biological and physiological mechanisms regulating the function of the immune system in the protection from diseases, and of the immune system pathology, with particular attention to hypersensitivity, autoimmunity and immunodeficiency; acquisition of the ability to consider the function of the immune system both in health and in disease status and of the bases of the most common laboratory immune techniques in order to become able to understand the results of any laboratory analysis based on immunological techniques; knowledge of the immune responses against infections, of both the congenital and the acquired disfunctions of the immune system, of the hypersensibility reactions and of the main autoimmune as well as lymphoproliferative diseases; knowledge of the immune strategies applied to the therapy of allergies and immunodeficiencies; knowledge of the general principles of vaccination therapy and immune suppression; kowledge of tumor immunology and immunology of transplantation.

Syllabus

Innate and acquired Immunity. Anatomy, cytology and biochemistry of the immune system: lymphoid organs, cells (lymphocytes, dendritic cells, macrophages, granulocytes, hemopoietic precursors), and molecules (immunoglobulins, T cell receptor, MHC molecules, co-stimulatory molecules). Cellular receptors of innate immunity, sensing of pathogen and damage patterns. Antigen processing and presentation. Cell-mediated and humoral immune response. The complement cascade. Cytokines, chemokines and cell-cooperation. Defense against infections. Immune tolerance. Hypersensibility reactions. Autoimmune diseases. Immunodeficiency. Immunity and tumors. Principles of immunotherapy. Immuno-hematology. Immunology of transplantation.

Reference books
Author Title Publisher Year ISBN Note
Cellular and Molecular Immunology A.K. ABBAS, A.H. LICHTMAN, S. PILLAI 2018
K. MURPHY, P. TRAVERS, M. WALPORT Janeway’s Immunobiology 2017
PETER PARHAM The immune system 2017

Assessment methods and criteria

Written test, based on questions with multiple choice answers., with eventual oral examination.





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