Bachelor's degree in Physiotherapy (to qualify as a physiotherapist) (Verona)

Pathology (2018/2019)

Course code
4S02742
Credits
4
Coordinator
Flavia Bazzoni

Teaching is organised as follows:
Unit Credits Academic sector Period Academic staff
FARMACOLOGIA 1 BIO/14-PHARMACOLOGY FISIO VR 2^ ANNO - 1^ SEMESTRE Guido Francesco Fumagalli
MICROBIOLOGIA 1 MED/07-MICROBIOLOGY AND CLINICAL MICROBIOLOGY FISIO VR 2^ ANNO - 1^ SEMESTRE Annarita Mazzariol
PATOLOGIA GENERALE 2 MED/05-CLINICAL PATHOLOGY FISIO VR 2^ ANNO - 1^ SEMESTRE Flavia Bazzoni

Learning outcomes

Aim of the course is to provide the student with the basic knowledge for the following processes:
• bacterial and viral infectious diseases;
• growth and spread of microorganisms and preventions of diffusion;
• mechanisms of action(s) of drugs. Tools to predict and manage therapeutic and toxic effects of principal drugs;
• mechanisms of cellular and molecular damage;
• pathogenetic processes;
• mechanisms aimed at the maintenance and recovery of the healthy state.

Syllabus

MICROBIOLOGY
• Microbiology introduction
• Bacteriology:
• bacterial cells and spore structure and functions.
• Bacterial replication
• Bacterial pathogenesis
• Virology:
• Virus structure and composition
• Viral replication
• Viral infections
• Way of infections transmission and preventions.

PHARMACOLOGY
Analysis of drug/receptor interaction and the generation of drug effect(s).
Terminology related to drug use, the methodologies of drug identification and clinical development.
Adverse reactions: classification and reporting
Analysis of the pharmacokinteic properties of drugs applied to patient treatment with detailed knowledge and understanding of : 1- drug absorption with emphasis on differences between routes of administration;2- drug distribution and elimination; 3- drug metabolism ; 4- quantitative approach to pharmacokinetics and the definition of a therapeutic regimen
Mechanims of action, classification, therapeutic effects and adverse reactions and clinical uses of antiinflammatory drugs
Mechanims of action of drugs active on the neuromuscular system

GENERAL PATHOLOGY
1. Introduction
General concepts
Homeostasis.
Pathogenesis
Etiology
Glossary

2. Cellular pathology
Pathogenesis of hypoxia, ischemia and oxidative stress.
Cellular death: apoptosis and necrosis
molecular markers of cell death

3. The innate immune response
Mononuclear phagocytes: features and functions
Acute inflammation: vascular changes and cellular events
Inflammatory exudate: characteristics and functions
Chemical Mediators and Regulators of Inflammation
Leucocyte recruitment
Leukocyte effector mechanisms ( phagocytosis, Killing and degradation of phagocytosed Microbes)
Systemic effects of inflammation
Outcomes of acute inflammation:
Chronic inflammation
Resolution: Regeneration and repair.
Scarring

4. Basic immunology
Innate and adaptive immunity: general concepts
Cells and tissues of the immune system
Overview of normal immune responses
Cellular and humoral immunity. Vaccines

5. Pathological changes of cellular differentiation and proliferation
Neoplasia (general concepts)
Morphological, molecular and functional features of the neoplastic cell
Nomenclature
Molecular bases of carcinogenesis: oncogenes and oncosuppressors

Assessment methods and criteria

written test

Reference books
Author Title Publisher Year ISBN Note
G.M. Pontieri Elementi di Patologia generale e Fisiopatologia Generale (Edizione 4) Piccin 2018 978-88-299-2912-2
A. Conforti, L. Cuzzolin, R. Leone, U. Moretti, G. Pignataro, M. Taglialatela, M. Vanzetta Farmacologia per le professioni sanitarie (Edizione 1) Idelson-Gnocchi 2015 978-88-7947-592-1
Harvey RA, Champe PC, Fisher BD Le basi della microbiologia Zanichelli 2008
Francesco Clementi e Guido Fumagalli Farmacologia generale e molecolare (Edizione 4) Edra S.p.A. 2016 978-88-214-4182-0
Simona De Grazia, D. Ferraro, G. Giammanco Microbiologia e microbiologia clinica per infermieri Pearson 2017
Mozzo Pierluigi Materiale didattico e informatico distribuito dal docente 2018




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