Bachelor's degree in Nursing (to qualify as a nurse) (Verona)

Biomolecular fondamentals of life [Matricole pari] (2018/2019)

Course code
4S000089
Credits
4
Coordinator
Cristina Bombieri

Teaching is organised as follows:
Unit Credits Academic sector Period Academic staff
BIOCHIMICA 2 BIO/10-BIOCHEMISTRY INF VR - 1° anno 1° sem Massimo Donadelli
BIOLOGIA APPLICATA 2 BIO/13-EXPERIMENTAL BIOLOGY INF VR - 1° anno 1° sem Cristina Bombieri

Learning outcomes

The course aims to develop knowledge of biology, biochemistry and genetics related to physiological and pathological processes in order to understand how health and disease changes in individuals at different stages of life. This knowledge will allow nursing students to understand which kind of cellular processes are common to all living organisms and in particular the basic mechanisms in the regulation of metabolic activity, reproduction and cellular interactions. Moreover the course will focus on the basic concepts of genetics, the most common genetic diseases, and their transmission rules.

Syllabus

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MM: BIOCHEMISTRY
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- Organic chemistry: nomenclature of organic compounds and recognition of functional groups.
- Carbohydrates: monosaccharides, disaccharides, polysaccharides.
- Proteins: amino acids, protein structure levels, peptide bond, allosteric regulation.
- Enzymes: Classification of enzymes, active site, specificity and isoenzymes, regulation of enzyme activity.
- Lipids: lipids and their functions, phospholipids, terpenes, cholesterol, lipoproteins.
- Introduction to metabolism: catabolism and anabolism, ATP and phosphocreatine, coenzymes redox, redox reactions, metabolic pathways and regulation, coupled reactions, signs of metabolism genetic defects.
- Carbohydrate metabolism: glycolysis, pentose phosphate pathway, alcoholic and lactic fermentation, Krebs cycle, gluconeogenesis, glycogenolysis and glycogen synthesis, hormone regulation, diabetes mellitus.
- Oxidative phosphorylation: mitochondrial respiratory chain, electron transport, ATP synthase.
- Lipid metabolism: beta-oxidation of fatty acids, lipid biosynthesis, fatty acid synthase, cholesterol metabolism.
- Metabolism of proteins and amino acids: transamination and oxidative deamination, glucose-alanine cycle, urea cycle.

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MM: EXPERIMENTAL BIOLOGY
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- Characteristics of the living beings. Origin of life and evolution. Cell Theory.
- Water: characteristics and biological importance.
- Eukaryotic and prokaryotic cell. Structure, function and organization of the cell.
- Roles and functions of the cell memebrane. Transport of molecules across cell membrane. Cell junctions.
- Cell signalling.
- Cell cycle. Mitosis and Meiosis. Cell death.
- Organisation of DNA in chromosome. Chromatin and chromosome structure and composition.
- Chromosomes and heredity. Normal and abnormal human karyotypes.
- Molecular basis of genetic information: DNA structure, function, replication and role in heredity.
- Definition of gene. Human genome and DNA mutation.
- Informational pathway: transcription, RNA processing, genetic code, mRNA translation and protein synthesis.
- Modes of transmission of hereditary characters and Mendel’s laws. Pedigree drawing.
- Genetic diseases. Somatic mutations and cancer.
- Genomics in medicine.

Assessment methods and criteria

The exam consists of 2 written tests, one for each module, to be passed simultaneously, based on all the issues covered throughout the course. In order to gain access to the biology test, students must have first discharged any training debts relating to the minimum biology knowledge.
To pass the exam, students must get a positive evaluation in both tests in the same exam and a global score of not less than 18/30. The final mark (/out of 30) will derive from the weighted average over credits of each single test score. Students can retire or refuse the proposed score and take the whole exam later.

Reference books
Author Title Publisher Year ISBN Note
Solomon, Martin, Martin, Berg Elementi di Biologia (Edizione 7) EdiSES 2017 978-88-7959-938-2
M. Samaja, R. Paroni Chimica e Biochimica Piccin 2016
Reece, Urry, Cain, Wasserman, Minorsky, Jackson Campbell - Biologia e Genetica (Edizione 1) Pearson 2015
Sadava, Hillis, Craig Heller, Hacker Elementi di Biologia e Genetica (Edizione 5) Zanichelli 2019 9788808820655




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