Combined Bachelor's + Master's degree in Medicine and Surgery

Chemistry and Biological chemistry (2018/2019)

Course code
4S01134
Credits
15
Coordinator
Marta Palmieri

Teaching is organised as follows:
Unit Credits Academic sector Period Academic staff
CHIMICA BIOLOGICA 8 BIO/10-BIOCHEMISTRY Lezioni 2° semestre 1°- 5° anno Marta Palmieri
CHIMICA E PROPEDEUTICA BIOCHIMICA 7 BIO/10-BIOCHEMISTRY Lezioni 1° semestre 1° anno Mariarita Bertoldi

Learning outcomes

Knowledge of the features of elements and compounds and of the principles that allow to understand their behaviour in biological systems; knowledge of reactivity of the different classes of organic compounds; to acquire of a solid chemical basis to allow interpretation of biochemical phenomena at a molecular level; knowledge of the structure-function relationship of proteins, sugars and lipids, of enzyme properties, and their reaction kinetics and catalytic mechanisms, of vitamins and hormones; knowledge of the pathways through which the livings synthetize and degrade sugars, lipids, amino acids and nucleotides, taking particular consideration to production and consumption of energy.

Syllabus

GENERAL CHEMISTRY
-Matter
- Chemical reactions and equations:
-Stoichiometriy
-Gas
-Thermochemistry
-Atom structure.
-More electronic devices
-The Periodic Character of Atomic Properties
- Chemical bonds
From atoms to molecules
- Weak intermolecular forces
-Solutions
- Chemical Equilibrium
- Reaction of acids and bases
-Thermodynamics
-Electrochemistry
-Chemical kinetics.

ORGANIC CHEMISTRY
-Carbon
-Hydrocarbons
-Benzene and aromatic compounds
-Stereoisomers: -Functional Groups and Definition of Families of Organic Compounds
-Bonds
-Organic reactions
-Organic macromolecules

BIOLOGICAL CHEMISTRY
-Proteins
-Enzymes
-Vitamins
-Lipids
-Carbohydrates
- Bioenergetics
- Glucid metabolism
- Lipid metabolism
- Protein metabolism
- Terminal metabolism
- Metabolic adjustment, tissue integration and signal transduction
- Nucleotide metabolism
- Vitamins

Assessment methods and criteria

The examination of the "Chemistry and Propedeutic Biochemistry" module is organized in written questions of stoichiometry, acid-base and oxidation reactions and an organic chemistry reaction mechanism. The oral examination, which can be accessed after passing the written questions, consists of a series of questions regarding the understanding of the topics of general chemistry, organic chemistry and propedeutics biochemistry carried out during the course.

The examination of the "Biological Chemistry" module consists of written questions with multiple responses, a description of biochemical reactions or metabolic pathways. The oral examination, which is accessible after passing the written questions, consists of an interview aimed at evaluating the student's ability to use chemical and biochemical knowledge for the interpretation of physiological and pathological phenomena in humans.

Reference books
Author Title Publisher Year ISBN Note
Catani et all Appunti di biochimica (Edizione 2) piccin 2017 978-88-299-2843-9
Garrett - Grisham Biochimica Piccin 2014
Mathews Biochimica Piccin 2014
Jeremy M Berg, John L Tymoczko, Lubert Stryer BIOCHIMICA (Edizione 7) Zanichelli 2012 9788808198730
Monica Stoppini, Vittorio Bellotti Biochimica applicata Edises 2012 9788879597135
Thomas M. Devlin Biochimica con aspetti clinici (Edizione 5) Edises 2013 9788879597807
Siliprandi - Tettamanti Biochimica Medica - Strutturale, metabolica e funzionale (Edizione 5) Piccin 2018 978-88-299-2791-3
Stefani M, Taddei N Chimica Biochimica e Biologia Applicata. Zanichelli ed., Bologna  
A. Fiecchi, M. Galli Kienle, A. Scala Chimica e propedeutica biochimica Edi-Ermes  
John R. Holum Elementi di chimica generale, organica e biologica. Zanichelli  
D. Voet, J. G. Voet, C.W. Pratt Fondamenti di Biochimica (Edizione 4) Zanichelli 2017 9788808420961
David L Nelson, Michael M Cox I principi di biochimica di Lehninger (Edizione 7) Zanichelli 2018 9788808920690
G. Meisenberg, W.H. Simmons Principi di Biochimica Medica Edizioni Minerva Medica 2013 978-88-7711-777-9
Bettelheim Chimica e Propedeutica Biochimica Edises 2015




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