Bachelor's degree in Nursing (to qualify as a nurse) (Vicenza)

Pathophysiology applied at Nursing - PATOLOGIA GENERALE

Course code
4S000090
Name of lecturer
Claudio Sorio
Number of ECTS credits allocated
2
Academic sector
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY
Language of instruction
Italian
Period
INF VI - 1° anno 2° sem dal Feb 1, 2018 al Mar 29, 2018.

To show the organization of the course that includes this module, follow this link * Course organization

Lesson timetable

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Learning outcomes


At the end of the course the student is expected to address the following subjects:

• Etiopathogenesis of cell damage
• Causes of alteration of cell function (chemical, physical and biological)
• Etiopathogenesis of disease. Concept of homeostasis and its regulation
• Acute and chronic inflammation
• Immune system: cell components, their function and interaction
• Homeostasis of the immune response, transfusion and transplants
• Molecular and cellular basis of neoplastic transformation

Syllabus

Introduction to pathology
• Cell homeostasis and alterations at the cell and organism levels
• The concept of biochemical lesion and subcellular localization
• Alteration of cell homeostasis: adaptation, necrosis, apoptosis, restoration of cell damage
• Examples of cell adaptation: alterations of cells status and differentiation

Causes of disease and mechanisms of cell damage
• General classification of the causes of disease: genetic (example: cystic fibrosis), environmental, multifactorial (example: atherosclerosis), chemical (example: alcohol), radiation, free radicals
• Mechanisms of healing

Oedema: pathogenesis and classification



Introduction to immunology and immunological damage

• Innate and acquired immunity: description of leukocytes involved and general mechanisms
• General features: antigen presentation, lymphocyte subclasses, complement
• MHC ad transplants
• Blood groups
• Mechanisms of immuological damage: anafilaxis, complement activation, role of antibodies and Fc receptor, cell-dependent cytotoxicity

Inflammation
• Role of blood vessels in inflammation
• Cells involved in inflammation
• Classification of inflammatory response based on prevalent features: erithematous, serous, fibrinous, purulent, necrotic-haemorragic
• Differences among acute and chronic inflammation
• Cytokines and their role in the regulation of the inflammatory response



Neoplasia

• Differences among benign and malign neoplasms
• Properties of neoplastic cells: growth, invasion and differentiation
• General classification: epithelial, mesenchimal, neuroectodermal and germinal, hemopoietc cells neoplasms
• Natural history of neoplasia: precancerous lesions, carcinoma in situ, metastasis. Preferential localization. TNM score.
• Molecular basis of neoplastic transformation: oncogenes and tumor suppressor genes. Mechanisms of activation/inhibition.
• Cancer etiology: physical, chemical and biological
• Mechanism of damage: compression, paraneoplastic syndromes, cachexia
• Cancer biomarkers and their clinical relevance

Reference books
Author Title Publisher Year ISBN Note
Giovanni M. Pontieri Patologia generale & fisiopatologia generale. Per i corsi di laurea in professioni sanitarie (Edizione 3) Piccin 2012 8829921424

Assessment methods and criteria

Quiz: multiple choices. Oral test for nursing science for the students that pass the written test. Oral exam at request or if deemed appropriate by the commission for the other themes.

STUDENT MODULE EVALUATION - 2017/2018






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