Combined Bachelor's + Master's degree in Medicine and Surgery

Laboratory Medicine (2017/2018)

Course code
4S02658
Credits
5
Coordinator
Giuseppe Lippi

Teaching is organised as follows:
Unit Credits Academic sector Period Academic staff
DIDATTICA PRATICA DI MEDICINA DI LABORATORIO 1 NN-- See the unit page See the unit page
BIOCHIMICA CLINICA - MEDICINA DI LABORATORIO 4 BIO/12-CLINICAL BIOCHEMISTRY AND MOLECULAR BIOLOGY Lezioni 2° semestre 1°- 5° anno Giuseppe Lippi

Learning outcomes

LABORATORY MEDICINE
At the end of the course the student will be able to apply choices and paths based on probabilistic criteria, usefulness and risk-benefit to the diagnostic process, being able to critically evaluate the Evidence-Based Medicine criteria (EBM). He/She will learn the value of Clinical Biochemistry on the diagnostic and therapeutic clinical decision making. The student will be finally able to guide the appropriate choice of laboratory tests and to correctly interpret their results, taking into account both interfering variables and confounding factors.

Syllabus

The course will develop with classroom lessons held by the official teachers of the course. These lessons are held in the morning hours and deal with subjects of discipline. In the morning time slot (8:00 to 14:00) each student will participate for 6 hours at a series of exercises performed both in the classroom (with aid of audiovisual and / or portable equipment) and in different locals of the Laboratory, in order to acquire knowledge about the total testing process, its activities and complexities and the potential clinical implications. Activity will always be carried out explored with the ongoing support of a tutor.

Specific course program
Knowledge of the pathophysiologic mechanisms and the interpretation of laboratory tests related to individual organs and tissues, mainly referring to the following topics:
• Hemocromocytometric examination,
• Hemostasis system,
• Glucose metabolism and diabetes,
• Lipid metabolism, atherosclerotic disease and complications,
• Acid-base and ions imbalance,
• Plasma proteins and inflammatory indices,
• Renal function,
• Hepatic function,
• Acute myocardial infarction,
• Enzymes in diagnosis and disease monitoring,
• Cancer biomarkers,
• Main endocrine disorders (thyroid, thrombocytopenia, gonads, phospho-calcium metabolism),
• Pregnancy monitoring,
• Applications of molecular biology
• Excerpts about major genetic diseases,
• Therapeutic monitoring

Assessment methods and criteria

Written, using structured text in multiple questions, short integrated clinical cases with responses, interpretation of lab data. Short oral examination in Laboratory Medicine topics for those passing the written test.
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Reference books
Author Title Publisher Year ISBN Note
Ciaccio M, Lippi G Biochimica Clinica e Medicina di Laboratorio (Edizione 2017) EdiSES Edizioni Scientifiche ed Universitarie 2017 9788879599580 Il volume descrive i principali aspetti organizzativi, analitici e clinici che caratterizzano il panorama della Biochimica Clinica e della Medicina di Laboratorio, con focus particolare sull’importanza della qualità e della sicurezza. L'elaborazione dei singoli capitoli è stata affidata da SIBioC a Soci di comprovata esperienza sull’argomento, al fine di poter descrive e discutere efficacemente lo stato dell’arte e i possibili sviluppi futuri della Medicina di Laboratorio e della scienza biomedica nel suo complesso e nella sua complessità.




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