Combined Bachelor's + Master's degree in Medicine and Surgery

Chemistry and Biological chemistry (2017/2018)

Course code
4S01134
Credits
15
Coordinator
Marta Palmieri

Teaching is organised as follows:
Unit Credits Academic sector Period Academic staff
CHIMICA BIOLOGICA 8 BIO/10-BIOCHEMISTRY Lezioni 2° semestre 1°- 5° anno Marta Palmieri
CHIMICA E PROPEDEUTICA BIOCHIMICA 7 BIO/10-BIOCHEMISTRY Lezioni 1° semestre 2°- 6° anno Mariarita Bertoldi

Learning outcomes

The course of Chemistry and Biomedical Chemistry aims to bring the student to: a) know the characteristics of elements and compounds and the principles that enable them to understand their behavior in biological systems; b) understand the reactivity of different classes of organic compounds in order to know how to interpret their behavior in biological systems; c) be able to perform elementary calculations with respect to the quantitative aspects of chemistry applied to Medical Sciences; d) acquire a solid chemical base to be able to interpret molecularly the phenomena described by biochemistry; e) know the structure and function of proteins, carbohydrates and lipids; f) understand the properties of enzymes, their kinetics of reaction and the catalytic mechanisms; g) acquire information on how living beens synthesize and degrade carbohydrates, lipids, amino acids and nucleotides with particular attention to energy production and consumption; h) know the structure and function of vitamins and hormones; i) understand how living organisms coordinate the thousands of reactions they catalyze; l) know particular topics of molecular and cell biochemistry such as transport in biological membranes, signal transduction, and molecular contraction mechanism; m) acquire useful information on diseases that result from biochemical defects.

Syllabus

GENERAL CHEMISTRY
-Matter
- Chemical reactions and equations:
-Stoichiometriy
-Gas
-Thermochemistry
-Atom structure.
-More electronic devices
-The Periodic Character of Atomic Properties
- Chemical bonds
From atoms to molecules
- Weak intermolecular forces
-Solutions
- Chemical Equilibrium
- Reaction of acids and bases
-Thermodynamics
-Electrochemistry
-Chemical kinetics.

ORGANIC CHEMISTRY
-Carbon
-Hydrocarbons
-Benzene and aromatic compounds
-Stereoisomers: -Functional Groups and Definition of Families of Organic Compounds
-Bonds
-Organic reactions
-Organic macromolecules

BIOLOGICAL CHEMISTRY
-Proteins
-Enzymes
-Vitamins
-Lipids
-Carbohydrates
- Bioenergetics
- Glucid metabolism
- Lipid metabolism
- Protein metabolism
- Terminal metabolism
- Metabolic adjustment, tissue integration and signal transduction
- Nucleotide metabolism
- Vitamins

Assessment methods and criteria

The examination of the "Chemistry and Propedeutic Biochemistry" module is organized in written questions of stoichiometry, acid-base and oxidation reactions and an organic chemistry reaction mechanism. The oral examination, which can be accessed after passing the written questions, consists of a series of questions regarding the understanding of the topics of general chemistry, organic chemistry and propedeutics biochemistry carried out during the course.

The examination of the "Biological Chemistry" module consists of written questions with multiple responses, a description of biochemical reactions or metabolic pathways. The oral examination, which is accessible after passing the written questions, consists of an interview aimed at evaluating the student's ability to use chemical and biochemical knowledge for the interpretation of physiological and pathological phenomena in humans.

Reference books
Author Title Publisher Year ISBN Note
Garrett - Grisham Biochimica Piccin 2014
Mathews Biochimica Piccin 2014
Jeremy M Berg, John L Tymoczko, Lubert Stryer BIOCHIMICA (Edizione 7) Zanichelli 2012 9788808198730
Thomas M. Devlin Biochimica con aspetti clinici (Edizione 5) Edises 2013 9788879597807
D. Voet, J. G. Voet, C.W. Pratt Fondamenti di Biochimica (Edizione 4) Zanichelli 2017 9788808420961
David L Nelson, Michael M Cox I principi di biochimica di Lehninger (Edizione 7) Zanichelli 2018 9788808920690
G. Meisenberg, W.H. Simmons Principi di Biochimica Medica Edizioni Minerva Medica 2013 978-88-7711-777-9




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