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MyUnivrTopic | Description | Research area |
---|---|---|
Biology and clinical application of adult stem cells | Biology and clinical application of adult stem cells, including: a) mesenchymal stromal cells: investigation of their differentiation potential and of their role in regenerative medicine, transplant-related immune reactions following allogeneic bone marrow transplantation, tumor-specific immune responses and stromal support to hematological and nonhematological malignancies; b) hematopoietic stem cells: in vitro expansion and in vivo transplantation; c) leukemia stem cells: study of the mechanisms of leukemia self-renewal, with particular interest in the role of the Notch and Wnt pathways in the stromal support to acute and chronic leukemia development, as potential targets for new drug development; d) neural stem cells: study of in vivo niches of neurogenesis; e) cardiac stem cells: study of the mechanisms of regeneration of infarcted myocardium; f) epithelial stem cells: study of the mechanism of wound healing and epithelial regeneration. |
Medicina di precisione
Medicina di precisione |
immunophenotype of acute and chronic leukemias | immunophenotypic characterization of acute and chronic leukemias |
Medicina di precisione
Medicina di precisione |
immunophenotype in malignant and non-malignant conditions | immunophenotypic and functional characterization and sorting of lymphoid subsets in peripheral blood and normal hemato-lymphopoietic tissues and in a number of malignant and non-malignant conditions |
Medicina di precisione
Medicina di precisione |
flow-cytometric monitoring of minimal residual disease | clinical application of flow-cytometric monitoring of minimal residual disease (MRD) in acute leukemia patients; he coordinated the use of this approach also in an Italian multicentre study (GIMEMA LAL0496) |
Medicina di precisione
Medicina di precisione |
Experimental studies in leukemias, lymphomas and multiple myeloma | In vitro studies on new therapeutic agents |
Medicina di precisione
Medicina di precisione |
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